About: Association between cytokine profiles and lung injury in COVID-19 pneumonia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between cytokine profiles and lung injury in COVID-19 pneumonia
Creator	Cai, Yu-Qing Chen, Li-Da Huang, Qiu-Fen Wang, Ming-Hui Wei, Xiao-Jie Zhang, Xiao-Bin Zhang, Zhen-Yu Yao, Weng-Zhen
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. METHODS: This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO(2)/FiO(2) ratio were used to assess lung injury. RESULTS: 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO(2)/FiO(2) were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO(2)/FiO(2) (β = − 0.434, p = 0.003). CONCLUSIONS: Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1186/s12931-020-01465-2
bibo:pmid	32727465
has license	cc-by
sha1sum (hex)	355e92b95213c2d1ed80372105d79c0f0226ee84
schema:url	https://doi.org/10.1186/s12931-020-01465-2
resource representing a document's title	Association between cytokine profiles and lung injury in COVID-19 pneumonia
has PubMed Central identifier	PMC7389162
has PubMed identifier	32727465
schema:publication	Respir Res
resource representing a document's body	covid:355e92b95213c2d1ed80372105d79c0f0226ee84#body_text
is schema:about of	named entity 'Coronavirus disease 2019' named entity 'COVID-19' named entity 'laboratory' named entity 'lymphocyte count' named entity 'caused' named entity 'signs' named entity 'profiles' named entity 'Association' named entity 'CORRELATION' named entity 'ANALYSIS' named entity 'LUNG INJURY' named entity 'COVID-19 PNEUMONIA' named entity 'pneumonia' named entity 'pneumonia' named entity 'assess' named entity 'log' named entity 'circulating' named entity 'ratio' named entity 'study' named entity 'TNF' named entity 'retrospective study' named entity 'disorder' named entity 'COVID-19' named entity 'FiO' named entity 'IL-6' named entity 'lung injury' named entity 'Correlation' named entity 'COVID-19' named entity 'pneumonia' named entity 'IL-6' named entity 'COVID-19' named entity 'IL-6' named entity 'COVID' named entity 'Correlation' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'retrospective study' named entity 'pneumonia' named entity 'IL-6' named entity 'COVID-19' named entity 'interleukin' named entity 'lung injury' named entity 'infection' named entity 'IL-2R' named entity 'prognosis' named entity 'IL-6R' named entity 'lung injury' named entity 'pneumonia' named entity 'cytokines' named entity 'multiorgan failure' named entity 'COVID-19' named entity 'fibrinogen' named entity 'COVID-19' named entity 'hemoglobin' named entity 'IFN' named entity '2, 3' named entity 'IL-6' named entity 'lung injury' named entity 'ALI' named entity 'COVID' named entity 'COVID' named entity 'Fujian' named entity 'pneumonia' named entity 'dependent variable' named entity 'pneumonia' named entity 'COVID' named entity 'COVID-19' named entity 'alveolar' named entity 'pneumonia' named entity 'membrane-bound' named entity 'IL-1' named entity 'IL-2R' named entity 'respiratory failure' named entity 'chest CT' named entity 'Student's t test'

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