About: A novel biosensor based on serum antibody immobilization for rapid detection of viral antigens

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About: A novel biosensor based on serum antibody immobilization for rapid detection of viral antigens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A novel biosensor based on serum antibody immobilization for rapid detection of viral antigens
Creator	Hanh, Hong Huy, Tran Nga, Thi Thi, Nguyen Thuy, Nguyen Tuan, Mai Van Chung, Pham
Source	Elsevier; Medline; PMC
abstract	Abstract In this paper, we represent a label-free biosensor based on immobilization of serum antibodies for rapid detection of viral antigens. Human serum containing specific antibodies against Japanese encephalitis virus (JEV) was immobilized on a silanized surface of an interdigitated sensor via protein A/glutaraldehyde for electrical detection of JEV antigens. The effective immobilization of serum antibodies on the sensor surface was verified by Fourier transform infrared spectrometry and fluorescence microscopy. The signal of the biosensor obtained by the differential voltage converted from the change into non-Faradic impedance resulting from the specific binding of JEV antigens on the surface of the sensor. The detection analyzed indicates that the detection range of this biosensor is 1–10μg/ml JEV antigens, with a detection limit of 0.75μg/ml and that stable signals are measured in about 20min. This study presents a useful biosensor with a high selectivity for rapid and simple detection of JEV antigens, and it also proposes the biosensor as a future diagnostic tool for rapid and direct detection of viral antigens in clinical samples for preliminary pathogenic screenings in the case of possible outbreaks.
has issue date	2011-10-30(xsd:dateTime)
bibo:doi	10.1016/j.talanta.2011.09.012
bibo:pmid	22063541
has license	els-covid
sha1sum (hex)	35774942278435cc157297f3ad033563eb20497f
schema:url	https://doi.org/10.1016/j.talanta.2011.09.012
resource representing a document's title	A novel biosensor based on serum antibody immobilization for rapid detection of viral antigens
has PubMed Central identifier	PMC7111752
has PubMed identifier	22063541
schema:publication	Talanta
resource representing a document's body	covid:35774942278435cc157297f3ad033563eb20497f#body_text
is schema:about of	named entity 'VIRAL ANTIGENS' named entity 'converted' named entity 'antigens' named entity 'IMMOBILIZATION' named entity 'USEFUL' named entity 'CLINICAL' named entity 'RAPID' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'SELECTIVITY' named entity 'ANTIBODIES' named entity 'DIRECT DETECTION' named entity 'BIOSENSOR' named entity 'DETECTION LIMIT' named entity 'REPRESENT' named entity 'DIAGNOSTIC TOOL' named entity 'RESULTING FROM' named entity '0.75' named entity 'PROTEIN A' named entity 'CASE' named entity 'ABOUT' named entity 'SCREENINGS' named entity 'NON-' named entity 'INTERDIGITATED' named entity '75 G' named entity '1-10' named entity 'SENSOR' named entity 'EFFECTIVE' named entity 'CONTAINING' named entity 'SURFACE' named entity 'POSSIBLE' named entity 'VOLTAGE' named entity 'NOVEL' named entity 'IMPEDANCE' named entity 'OUTBREAKS' named entity 'PRESENTS' named entity 'ELECTRICAL' named entity 'SAMPLES' named entity 'SIMPLE' named entity 'PRELIMINARY' named entity 'PAPER' named entity 'PATHOGENIC' named entity 'FLUORESCENCE MICROSCOPY' named entity 'SIGNAL' named entity 'HUMAN SERUM' named entity 'ANTIBODY' named entity 'IMMOBILIZATION' named entity 'BASED' named entity 'SERUM' named entity 'ANTIGENS' named entity 'BINDING' named entity 'STABLE' named entity 'LABEL-FREE' named entity 'FOURIER TRANSFORM INFRARED SPECTROMETRY' named entity 'ANALYZED' named entity 'FUTURE' named entity 'STUDY' named entity 'RANGE' named entity 'BASED' named entity 'SPECIFIC' named entity 'MEASURED' named entity 'THE CHANGE' named entity 'DIFFERENTIAL' named entity 'MIN' named entity 'VIRAL ANTIGENS' named entity 'DETECTION' named entity 'HIGH' named entity 'SERUM' named entity 'OBTAINED BY' named entity 'RAPID' named entity 'DETECTION' named entity 'BIOSENSOR' named entity 'VERIFIED' covid:arg/35774942278435cc157297f3ad033563eb20497f named entity 'samples' named entity 'future'

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