About: An outbreak of acute respiratory infection at a training base in Beijing, China due to human adenovirus type B55

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About: An outbreak of acute respiratory infection at a training base in Beijing, China due to human adenovirus type B55 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An outbreak of acute respiratory infection at a training base in Beijing, China due to human adenovirus type B55
Creator	Wang, Quanyi Yang, Peng Zhang, Li Sun, Ying Zhang, Daitao Liu, Yimeng Lu, Guilan Peng, Xiaomin Li, Renqing Zhao, Jiachen Wang, Xifeng Wu, Zhanguo
Source	Medline; PMC
abstract	BACKGROUND: Twelve students experienced symptoms of acute respiratory infection (ARI) at a training base in Beijing from August 26 to August 30, 2015. We investigated the cause of this ARI outbreak. METHODS: In partnership with the local center for disease control, we collected a total of twelve pharyngeal swab specimens as well as demographic information for the affected patients. We used multiplex real-time PCR to screen for sixteen common respiratory viruses in these samples. To isolate HAdV, we inoculated Hep-2 cells with the human adenovirus (HAdV)-positive samples and then carried out sequencing and phylogenetic analysis of the hexon, fiber, and penton genes of the isolated adenoviruses. In addition, we analyzed the entire genome of one strain isolated from the index case to identify single-nucleotide substitutions. RESULTS: We identified ten HAdV-positive students using multiplex real-time PCR. None of the students were co-infected with other viruses. We successfully isolated seven HAdV strains from the pharyngeal swab specimens. The coding sequences of the hexon, fiber, and penton genes of these seven HAdV strains were identical, suggesting that they represented seven strains from a single virus clone. One HAdV isolate obtained from the index case, BJDX-01-2015, was selected for whole genome analysis. From this isolate, we obtained a 34,774-nucleotide sequence. The genome of BJDX-01-2015 clustered with HAdV-B55 in phylogenetic analyses and had 99.97% identity with human adenovirus 55 isolate HAdV-B/CHN/BJ01/2011/55 (GenBank accession no. JX491639). CONCLUSIONS: We identified HAdV-B55 as the strain associated with the August 2015 ARI outbreak at a training base in Beijing. This was the first reported outbreak in Beijing due to HAdV-B55. Continuous surveillance of respiratory adenoviruses is urgently needed to understand the epidemiological and evolutionary features of HAdV-B55, and an epidemiological modeling approach may provide further insights into this emerging public health threat. Furthermore, the clinical laboratory data from this outbreak provides important reference for the clinical diagnosis and may ultimately aid in informing the development of strategies to control and prevent respiratory tract infections caused by HAdV-B55.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.1186/s12879-020-05258-2
bibo:pmid	32703176
has license	cc-by
sha1sum (hex)	35a08510bd609d38883d6273fa4855c11f5ee3c6
schema:url	https://doi.org/10.1186/s12879-020-05258-2
resource representing a document's title	An outbreak of acute respiratory infection at a training base in Beijing, China due to human adenovirus type B55
has PubMed Central identifier	PMC7376533
has PubMed identifier	32703176
schema:publication	BMC Infect Dis
resource representing a document's body	covid:35a08510bd609d38883d6273fa4855c11f5ee3c6#body_text
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