About: Interaction of mouse hepatitis virus 3 with Kupffer cells explanted from susceptible and resistant mouse strains. Antiviral activity, interleukin-1 synthesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interaction of mouse hepatitis virus 3 with Kupffer cells explanted from susceptible and resistant mouse strains. Antiviral activity, interleukin-1 synthesis
Creator	Keller, F Kirn, A Schmitt, C
source	PMC
abstract	The genetic sensitivity of mouse strains to mouse hepatitis virus 3 (MHV 3) has been related in vitro to a delay of virus replication in liver sinusoidal cells. In vivo immuno-histochemical studies of the liver from infected mice have demonstrated that mechanisms other than direct viral injury are in operation. To examine potential mechanisms, the interaction of lipopolysaccharide (LPS)-stimulated Kupffer cells with MHV 3 was studied. We first observed a dramatic inhibition in viral replication in LPS-treated Kupffer cells explanted from A/J resistant mice. Second, we demonstrated that MHV 3 induced a dose-dependent interleukin 1 (IL-1) activity in the supernatants of infected Kupffer cells of both strains. These results led us finally to examine the antigen-proceesing function of the Kupffer cellsof both strains of mice. No striking differences were observed in the ability of Kupffer cells from resistant or sensitive mice to collaborate with immunocompetent lymphocytes. Our data suggest that Kupffer cells play a double role which is crucial in the pathogenesis of MHV 3-induced hepatitis. First, they act directly as the genetically determined sensitivity of mice to MHV 3 infection is correlated with the efficiency of the antiviral activity induced in Kupffer cells by LPS. Second, they act indirectly through the synthesis of different amounts of IL-1 induced by MHV 3. This hypothesis is further borne out by the effects of indomethacin treatment on the course of MHV 3 infection in A/J resistant mice in vivo.
has issue date	1988-07-01(xsd:dateTime)
bibo:doi	10.1111/j.1574-6968.1988.tb02496.x
bibo:pmid	2856206
has license	no-cc
sha1sum (hex)	35ac0051e5ac088a9d24c3cc287df3c6d5cc4b90
schema:url	https://doi.org/10.1111/j.1574-6968.1988.tb02496.x
resource representing a document's title	Interaction of mouse hepatitis virus 3 with Kupffer cells explanted from susceptible and resistant mouse strains. Antiviral activity, interleukin-1 synthesis
has PubMed Central identifier	PMC7110325
has PubMed identifier	2856206
schema:publication	FEMS Microbiol Immunol
resource representing a document's body	covid:35ac0051e5ac088a9d24c3cc287df3c6d5cc4b90#body_text
is schema:about of	named entity 'RESISTANT' named entity 'ANTIVIRAL ACTIVITY' named entity 'MOUSE STRAINS' named entity 'KUPFFER CELLS' named entity 'INTERACTION' named entity 'SUSCEPTIBLE' named entity 'MOUSE HEPATITIS VIRUS' named entity 'INTERLEUKIN-1 SYNTHESIS' named entity 'EXPLANTED' named entity 'Kupffer cells' named entity 'Kupffer cells' named entity 'mouse hepatitis virus' named entity 'LPS' named entity 'virus' named entity 'Kupffer cell' named entity 'indomethacin' named entity 'Histological' named entity 'thymocyte' named entity 'supernatant' named entity 'macrophages' named entity 'monocytes' named entity 'macrophages' named entity 'infection' named entity 'Kupffer cells' named entity 'thymocyte' named entity 'Kupffer cells' named entity 'erythrocytes' named entity 'pathogenesis' named entity 'incubation' named entity 'virus' named entity 'LPS' named entity 'Balb/c' named entity 'LPS' named entity 'IL-1' named entity 'glutamine' named entity 'indomethacin' named entity 'IL-1' named entity 'thymidine' named entity 'Balb/c' named entity 'antigen' named entity 'immunocompetent' named entity 'hepatic' named entity 'virus' named entity 'vascular endothelial cells' named entity 'LPS' named entity 'IL-1' named entity 'lymphocytes' named entity 'cytopathic effect' named entity 'Kupffer cells' named entity 'Kupffer cells' named entity 'Kupffer cells' named entity 'indomethacin' named entity 'indomethacin' named entity 'aseptic techniques' named entity 'endothelial' named entity 'coronavirus' named entity 'Kupffer cells' named entity 'antiviral activity' named entity 'microcirculation' named entity 'indomethacin' named entity 'IL-1' named entity 'macrophage' named entity 'infection' named entity 'elutriation' named entity 'hepatitis' named entity 'Mouse hepatitis virus' named entity '37°C' named entity 'virus' named entity 'Kupffer cells' named entity 'particulates' named entity 'Hepes' named entity 'IL-1' named entity 'liver' named entity '37°C' named entity 'parenchymal' named entity 'IL-1' named entity 'dose dependent' named entity 'procoagulant' named entity 'macrophages'

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