About: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

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About: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
Creator	Lely, A Hamming, I Navis, G Timens, W Bulthuis, Mlc Van Goor, H
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct coronavirus (SARS‐CoV) has been identified as the aetiological agent of SARS. Recently, a metallopeptidase named angiotensin‐converting enzyme 2 (ACE2) has been identified as the functional receptor for SARS‐CoV. Although ACE2 mRNA is known to be present in virtually all organs, its protein expression is largely unknown. Since identifying the possible route of infection has major implications for understanding the pathogenesis and future treatment strategies for SARS, the present study investigated the localization of ACE2 protein in various human organs (oral and nasal mucosa, nasopharynx, lung, stomach, small intestine, colon, skin, lymph nodes, thymus, bone marrow, spleen, liver, kidney, and brain). The most remarkable finding was the surface expression of ACE2 protein on lung alveolar epithelial cells and enterocytes of the small intestine. Furthermore, ACE2 was present in arterial and venous endothelial cells and arterial smooth muscle cells in all organs studied. In conclusion, ACE2 is abundantly present in humans in the epithelia of the lung and small intestine, which might provide possible routes of entry for the SARS‐CoV. This epithelial expression, together with the presence of ACE2 in vascular endothelium, also provides a first step in understanding the pathogenesis of the main SARS disease manifestations. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
has issue date	2004-05-07(xsd:dateTime)
bibo:doi	10.1002/path.1570
bibo:pmid	15141377
has license	no-cc
sha1sum (hex)	362236d2605f30945aae8b0164150cd88944e4bb
schema:url	https://doi.org/10.1002/path.1570
resource representing a document's title	Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
has PubMed Central identifier	PMC7167720
has PubMed identifier	15141377
schema:publication	J Pathol
resource representing a document's body	covid:362236d2605f30945aae8b0164150cd88944e4bb#body_text
is schema:about of	named entity 'arterial' named entity 'SARS-CoV' named entity 'venous' named entity 'ACE2' named entity 'PATHOGENESIS' named entity 'VASCULAR ENDOTHELIUM' named entity 'RECENTLY' named entity 'METALLOPEPTIDASE' named entity 'LARGELY' named entity 'HUMAN' named entity 'PROTEIN EXPRESSION' named entity 'TREATMENT' named entity 'SARS' named entity 'PROVIDE' named entity 'ROUTE' named entity 'STRATEGIES' named entity 'mRNA' named entity 'enterocytes' named entity 'Since' named entity 'ACE2' named entity 'small intestine' named entity 'expression' named entity 'ACE2' named entity 'pathogenesis' named entity 'ACE2' named entity 'bone marrow' named entity 'ACE2' named entity 'distribution' named entity 'protein' named entity 'thymus' named entity 'pathogenesis' named entity 'ACE2' named entity 'SARS disease' named entity 'receptor' named entity 'aetiological' named entity 'coronavirus' named entity 'ACE2' named entity 'ACE2' named entity 'SARS coronavirus' named entity 'staining' named entity 'mRNA expression' named entity 'PBS' named entity 'ACE2' named entity 'type II pneumocytes' named entity 'SARS-CoV' named entity 'human organs' named entity 'pathologist' named entity 'alveolar' named entity 'PBS' named entity 'vascular smooth muscle cells' named entity 'cytoplasm' named entity 'staining' named entity 'ACE2' named entity 'staining' named entity 'viral replication' named entity 'SARS-CoV' named entity 'small intestine' named entity 'stomach' named entity 'kidney' named entity 'brush border' named entity 'spleen' named entity 'SARS-CoV' named entity 'enterocytes' named entity 'autopsy' named entity 'endothelium' named entity 'ACE2' named entity 'CD4' named entity 'staining' named entity 'SARS-CoV' named entity 'ACE2' named entity 'RNA' named entity 'ACE2' named entity 'ACE2' named entity 'lung' named entity 'inflammatory' named entity 'Netherlands'

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