About: Endocrine Disruption and Obesity: A current review on Environmental Obesogens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Endocrine Disruption and Obesity: A current review on Environmental Obesogens
Creator	Kumar, Prashant Avtar, Dr Dutta, Sriparna Fahmi, Nighat Garg, Bhaskar Gupta, Radhika Karani, Vimaleswaran Matharu, Avtar Matharu, S Sachar, Shilpee Sinclair, Hugh Vimaleswaran, Karani
Source	Elsevier; PMC
abstract	Abstract Obesity represents an important public health concern because it substantially increases the risk of multiple chronic diseases and thereby contributing to a decline in both quality of life and life expectancy. Besides unhealthy diet, physical inactivity and genetic susceptibility, environmental pollutants also contribute to the rising prevalence of obesity epidemic. An environmental obesogen is defined as a chemical that can alter lipid homeostasis to promote adipogenesis and lipid accumulation whereas an endocrine disrupting chemical (EDC) is defined as a synthetic chemical that can interfere with the endocrine function and cause adverse health effects. Many obesogens are EDCs that interfere with normal endocrine regulation of metabolism, adipose tissue development and maintenance, appetite, weight and energy balance. An expanding body of scientific evidence from animal and epidemiological studies has begun to provide links between exposure to EDCs and obesity. Despite the significance of environmental obesogens in the pathogenesis of metabolic diseases, the contribution of synthetic chemical exposure to obesity epidemic remains largely unrecognised. Hence, the purpose of this review is to provide a current update on the evidences from animal and human studies on the role of fourteen environmental obesogens in obesity, a comprehensive view of the mechanisms of action of these obesogens and current green and sustainable chemistry strategies to overcome chemical exposure to prevent obesity. Designing of safer version of obesogens through green chemistry approaches requires a collaborative undertaking to evaluate the toxicity of endocrine disruptors using appropriate experimental methods, which will help in developing a new generation of inherently safer chemicals.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1016/j.crgsc.2020.06.002
has license	els-covid
sha1sum (hex)	3641ed2538375b20abace5144f640eece948a1fa
schema:url	https://doi.org/10.1016/j.crgsc.2020.06.002
resource representing a document's title	Endocrine Disruption and Obesity: A current review on Environmental Obesogens
has PubMed Central identifier	PMC7326440
resource representing a document's body	covid:3641ed2538375b20abace5144f640eece948a1fa#body_text
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