About: Interplay between platelets and coagulation

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interplay between platelets and coagulation
Creator	Huskens, Dana Roest, Mark Sang, Yaqiu De Groot, Philip De Laat, Bas
Source	Elsevier; Medline; PMC
abstract	Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood vessels through clot formation. This regulated physiological process consists of complex interactions between endothelial cells, platelets, von Willebrand factor and coagulation factors. Haemostasis is initiated by a damaged vessel wall, followed with a rapid adhesion, activation and aggregation of platelets to the exposed subendothelial extracellular matrix. At the same time, coagulation factors aggregate on the procoagulant surface of activated platelets to consolidate the platelet plug by forming a mesh of cross-linked fibrin. Platelets and coagulation mutually influence each other and there are strong indications that, thanks to the interplay between platelets and coagulation, haemostasis is far more effective than the two processes separately. Clinically this is relevant because impaired interaction between platelets and coagulation may result in bleeding complications, while excessive platelet-coagulation interaction induces a high thrombotic risk. In this review, platelets, coagulation factors and the complex interaction between them will be discussed in detail.
has issue date	2020-07-12(xsd:dateTime)
bibo:doi	10.1016/j.blre.2020.100733
bibo:pmid	32682574
has license	no-cc
sha1sum (hex)	366a7f2816fdec54dd41f8600f7f1c42a6429d33
schema:url	https://doi.org/10.1016/j.blre.2020.100733
resource representing a document's title	Interplay between platelets and coagulation
has PubMed Central identifier	PMC7354275
has PubMed identifier	32682574
schema:publication	Blood Rev
resource representing a document's body	covid:366a7f2816fdec54dd41f8600f7f1c42a6429d33#body_text
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