About: Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association?
Creator	María, José Escamilla-Sevilla, Francisco Giménez, Ruiz Jc, Romero-Fábrega María Barrios-López, José Muñoz Martínez, Claudia Rego-García, Iago Rodríguez, Rivero Antonio Ruiz Giménez, Jesús Barrios-López, J Correo, Dolores Fernández Pérez, María Escamilla-Sevilla, F Fernández Pérez, Jm, Barrios-López López, Barrios Martínez, Muñoz Muñoz Martínez, C Mínguez-Castellanos, A Mínguez-Castellanos, Adolfo Rego-García, Rego-García, I Rivero Rodríguez, M Rivero Rodríguez, Mar Romero-Fábrega, J Romero-Fábrega, Juan Ruiz Giménez, J
Source	Elsevier; PMC
abstract	Abstract Introduction Ischaemic stroke has been reported in patients with COVID-19, particularly in more severe cases. However, it is unclear to what extent this is linked to systemic inflammation and hypercoagulability secondary to the infection. Materials and methods We describe the cases of 4 patients with ischaemic stroke and COVID-19 who were attended at our hospital. Patients are classified according to the likelihood of a causal relationship between the hypercoagulable state and ischaemic stroke. We also conducted a review of studies addressing the possible mechanisms involved in the aetiopathogenesis of ischaemic stroke in these patients. Results The association between COVID-19 and stroke was probably causal in 2 patients, who presented cortical infarcts and had no relevant arterial or cardioembolic disease, but did show signs of hypercoagulability and systemic inflammation in laboratory analyses. The other 2 patients were of advanced age and presented cardioembolic ischaemic stroke; the association in these patients was probably incidental. Conclusions Systemic inflammation and the potential direct action of the virus may cause endothelial dysfunction, resulting in a hypercoagulable state that could be considered a potential cause of ischaemic stroke. However, stroke involves multiple pathophysiological mechanisms; studies with larger samples are therefore needed to confirm our hypothesis. The management protocol for patients with stroke and COVID-19 should include a complete aetiological study, with the appropriate safety precautions always being observed.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1016/j.nrleng.2020.05.008
has license	els-covid
sha1sum (hex)	36e08484f476eba164be23d47a79e9c1a3411765
schema:url	https://doi.org/10.1016/j.nrleng.2020.05.008
resource representing a document's title	Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association?
has PubMed Central identifier	PMC7253983
resource representing a document's body	covid:36e08484f476eba164be23d47a79e9c1a3411765#body_text
is schema:about of	named entity 'graves' named entity 'causal' named entity 'incidental' named entity 'COVID-19' named entity 'infection' named entity 'Ischaemic stroke' named entity 'infección' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SIN' named entity 'infección' named entity 'SARS-CoV-2' named entity 'infection' named entity 'Ischaemic stroke' named entity 'A1S' named entity 'COVID-19' named entity 'embargo' named entity 'ictus' named entity 'mayor' named entity 'SARS-CoV-2' named entity 'Sin' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'más' named entity 'incidental' named entity 'infection' named entity 'stroke' named entity 'causal' named entity 'causal' named entity 'PRE' named entity 'SARS-COV-2' named entity 'INCIDENTAL' named entity 'SARS-CoV-2' named entity 'stroke' named entity 'infection' named entity 'Ictus' named entity 'Journal' named entity 'MAYOR' named entity 'ADA ' named entity 'N A' named entity 'ESTAR' named entity 'JOURNAL ' named entity 'PROOF' named entity 'SARS-COV-2 INFECTION' named entity 'ISCHAEMIC STROKE' named entity 'ASSOCIATION' named entity 'POR'
is part of of	covid:36e08484f476eba164be23d47a79e9c1a3411765#body_text Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association? Abstract Introduction Ischaemic stroke has been reported in patients with COVID-19, particularly in more severe cases. However, it is unclear to what extent this is linked to systemic inflammation and hypercoagulability secondary to the infection. Materials and methods We describe the cases of 4 patients with ischaemic stroke and COVID-19 who were attended at our hospital. Patients are classified according to the likelihood of a causal relationship between the hypercoagulable state and ischaemic stroke. We also conducted a review of studies addressing the possible mechanisms involved in the aetiopathogenesis of ischaemic stroke in these patients. Results The association between COVID-19 and stroke was probably causal in 2 patients, who presented cortical infarcts and had no relevant arterial or cardioembolic disease, but did show signs of hypercoagulability and systemic inflammation in laboratory analyses. The other 2 patients were of advanced age and presented cardioembolic ischaemic stroke; the association in these patients was probably incidental. Conclusions Systemic inflammation and the potential direct action of the virus may cause endothelial dysfunction, resulting in a hypercoagulable state that could be considered a potential cause of ischaemic stroke. However, stroke involves multiple pathophysiological mechanisms; studies with larger samples are therefore needed to confirm our hypothesis. The management protocol for patients with stroke and COVID-19 should include a complete aetiological study, with the appropriate safety precautions always being observed.

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