About: Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus
Creator	Brooks, Gavin Dove, Brian You, Jae-Hwan Hiscox, Julian Reed, Mark Emmett, Stevan
Source	Medline; PMC
abstract	The nucleolus is a dynamic subnuclear structure involved in ribosome subunit biogenesis, cell cycle control and mediating responses to cell stress, among other functions. While many different viruses target proteins to the nucleolus and recruit nucleolar proteins to facilitate virus replication, the effect of infection on the nucleolus in terms of morphology and protein content is unknown. Previously we have shown that the coronavirus nucleocapsid protein will localize to the nucleolus. In this study, using the avian infectious bronchitis coronavirus, we have shown that virus infection results in a number of changes to the nucleolus both in terms of gross morphology and protein content. Using confocal microscopy coupled with fluorescent labelled nucleolar marker proteins we observed changes in the morphology of the nucleolus including an enlarged fibrillar centre. We found that the tumour suppressor protein, p53, which localizes normally to the nucleus and nucleolus, was redistributed predominately to the cytoplasm.
has issue date	2006-03-03(xsd:dateTime)
bibo:doi	10.1111/j.1462-5822.2006.00698.x
bibo:pmid	16819967
has license	no-cc
sha1sum (hex)	3716e5bad9d8f7ed3d8417a10c87bd29c224ac1a
schema:url	https://doi.org/10.1111/j.1462-5822.2006.00698.x
resource representing a document's title	Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virus
has PubMed Central identifier	PMC7162191
has PubMed identifier	16819967
schema:publication	Cell Microbiol
resource representing a document's body	covid:3716e5bad9d8f7ed3d8417a10c87bd29c224ac1a#body_text
is schema:about of	named entity 'morphology' named entity 'fibrillar' named entity 'labelled' named entity 'While' named entity 'nucleolus' named entity 'protein' named entity 'cell cycle' named entity 'replication' named entity '2C CELL' named entity 'localize' named entity 'protein' named entity 'terms' named entity 'target' named entity 'fluorescent' named entity 'nucleolus' named entity 'proteins' named entity 'content' named entity 'structure' named entity 'virus' named entity 'avian infectious bronchitis' named entity 'cell cycle control' named entity 'cell stress' named entity 'viruses' named entity 'nucleocapsid protein' named entity 'confocal microscopy' named entity 'morphology' named entity 'coronavirus' named entity 'coronavirus' named entity 'nucleus' named entity 'cell cycle' named entity 'bright field' named entity 'expression vector' named entity 'cell nuclei' named entity 'nucleocapsid' named entity 'reducing conditions' named entity 'Clontech' named entity 'fluorescently tagged' named entity 'nuclei' named entity 'Proteomic analysis' named entity 'nucleoli' named entity 'protein' named entity 'IBV' named entity 'nucleolus' named entity 'Alexa Fluor' named entity '2.0' named entity 'protein' named entity 'DFC' named entity 'C-terminal' named entity 'IBV' named entity 'polyclonal antibody' named entity 'Texas' named entity 'ribosomal' named entity 'nucleolin' named entity 'nucleocapsid' named entity 'fixed and stained' named entity 'phosphorylated' named entity 'nucleolus' named entity 'protein content' named entity 'nucleolus' named entity 'protein' named entity 'EGFP' named entity 'nucleolus' named entity 'microscope' named entity 'GAPDH' named entity 'nucleocapsid' named entity 'protein' named entity 'IBV' named entity 'nucleolin' named entity 'IBV' named entity 'EGFP' named entity 'nucleoli' named entity 'protein' named entity 'p53' named entity 'amino-acid' named entity 'nucleic acid' named entity 'protein'

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