About: Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection

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About: Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
Creator	King, Catherine Bourke, Nollaig Mclaughlin, Anne Bergin, Colm Hopkins, David O'connor, Laura Townsend, Liam Jones, Karen Cheallaigh, Cliona Byrne, Patricia Cox, Fionnuala Dowds, Joanne Dunne, Jean Dyer, Adam Gaffney, Fiona Kiersey, Rachel Kingston, Tara Leavy, Deirdre Mooney, Aoife Nadarajan, Parthiban O'brien, Kate Ridge, Katie Sugrue, Jamie
Source	MedRxiv
abstract	Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it is unknown if COVID-19 results in persistent fatigue in those recovered from acute infection. We examined the prevalence of fatigue in individuals recovered from the acute phase of COVID-19 illness using the Chalder Fatigue Score (CFQ-11). We further examined potential predictors of fatigue following COVID-19 infection, evaluating indicators of COVID-19 severity, markers of peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 {+/-} 15 years; 54% female), more than half reported persistent fatigue (52.3%; 45/128) at 10 weeks (median) after initial COVID-19 symptoms. There was no association between COVID-19 severity (need for inpatient admission, supplemental oxygen or critical care) and fatigue following COVID-19. Additionally, there was no association between routine laboratory markers of inflammation and cell turnover (leukocyte, neutrophil or lymphocyte counts, neutrophil-to-lymphocyte ratio, lactate dehydrogenase, C-reactive protein) or pro-inflammatory molecules (IL-6 or sCD25) and fatigue post COVID-19. Female gender and those with a pre-existing diagnosis of depression/anxiety were over-represented in those with fatigue. Our findings demonstrate a significant burden of post-viral fatigue in individuals with previous SARS-CoV-2 infection after the acute phase of COVID-19 illness. This study highlights the importance of assessing those recovering from COVID-19 for symptoms of severe fatigue, irrespective of severity of initial illness, and may identify a group worthy of further study and early intervention.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1101/2020.07.29.20164293
has license	medrxiv
sha1sum (hex)	372cb080e4e835478d1d25e63db60965601a0e85
schema:url	https://doi.org/10.1101/2020.07.29.20164293
resource representing a document's title	Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
resource representing a document's body	covid:372cb080e4e835478d1d25e63db60965601a0e85#body_text
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