About: Ebola virus disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ebola virus disease
Creator	Bollinger, Laura Crozier, Ian Jacob, Shevin Kraft, Colleen Kuhn, Jens De, Marc-Antoine Hewlett, Angela Ii, William Vega, La Griffiths, Anthony Soka, Moses Wahl, Victoria
Source	PMC
abstract	Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission, followed by human-to-human transmission via direct contact or contact with infected bodily fluids or contaminated fomites. EVD has a high case–fatality rate; it is characterized by fever, gastrointestinal signs and multiple organ dysfunction syndrome. Diagnosis requires a combination of case definition and laboratory tests, typically real-time reverse transcription PCR to detect viral RNA or rapid diagnostic tests based on immunoassays to detect EBOV antigens. Recent advances in medical countermeasure research resulted in the recent approval of an EBOV-targeted vaccine by European and US regulatory agencies. The results of a randomized clinical trial of investigational therapeutics for EVD demonstrated survival benefits from two monoclonal antibody products targeting the EBOV membrane glycoprotein. New observations emerging from the unprecedented 2013–2016 Western African EVD outbreak (the largest in history) and the ongoing EVD outbreak in the Democratic Republic of the Congo have substantially improved the understanding of EVD and viral persistence in survivors of EVD, resulting in new strategies toward prevention of infection and optimization of clinical management, acute illness outcomes and attendance to the clinical care needs of patients.
has issue date	2020-02-20(xsd:dateTime)
bibo:doi	10.1038/s41572-020-0147-3
bibo:pmid	32080199
has license	no-cc
sha1sum (hex)	373395340c84705638d47deb2057d48d930ca3fd
schema:url	https://doi.org/10.1038/s41572-020-0147-3
resource representing a document's title	Ebola virus disease
has PubMed Central identifier	PMC7223853
has PubMed identifier	32080199
schema:publication	Nat Rev Dis Primers
resource representing a document's body	covid:373395340c84705638d47deb2057d48d930ca3fd#body_text
is schema:about of	named entity 'targeting' named entity 'antigens' named entity 'improved' named entity 'prevention' named entity 'immunoassays' named entity 'reverse transcription PCR' named entity 'outbreak' named entity 'typically' named entity 'infected' named entity 'gastrointestinal' named entity 'typically' named entity 'Ebola virus' named entity 'survival' named entity 'case-fatality rate' named entity 'Sierra Leone' named entity 'filovirus' named entity 'EBOV' named entity 'vomiting' named entity 'virus' named entity 'EVD' named entity 'public health surveillance' named entity 'Uganda' named entity 'Democratic Republic of the Congo' named entity 'bacterial translocation' named entity 'social isolation' named entity 'epidemic' named entity 'endotracheal tube' named entity 'Kidney' named entity 'feces' named entity 'EVD' named entity 'glucose' named entity 'IgM' named entity 'acute kidney injury' named entity 'blood samples' named entity 'EBOV' named entity 'IL-1β' named entity 'reverse transcription' named entity 'symptom' named entity 'EBOV' named entity 'EVD' named entity 'nonhuman primates' named entity 'uveitis' named entity 'fever' named entity 'EVD' named entity '2016' named entity 'EBOV' named entity 'RNA' named entity 'viral' named entity 'fomites' named entity 'Democratic Republic of the Congo' named entity 'rapid diagnostic tests' named entity 'EVD' named entity 'EBOV' named entity 'EVD' named entity 'antigens' named entity 'EVD' named entity 'single case' named entity 'infection' named entity 'fever' named entity 'Ebola virus disease' named entity 'SUDV' named entity 'liver' named entity 'virus' named entity 'Democratic Republic of the Congo' named entity 'communicable diseases' named entity 'FVD' named entity 'crab-eating macaques' named entity 'conjunctival' named entity 'virus entry' named entity 'International Classification of Diseases'

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