About: Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)

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About: Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)
Creator	Paranhos-Baccalà, Gláucia Shen, Kunling Vernet, Guy Wang, Jianwei Vanhems, Philippe Komurian-Pradel, Florence Nymadawa, Pagbajabyn Awasthi, Shally Barreto, Patricia Basualdo, Wilma Bavdekar, Ashish Bénet, Thomas Chou, Monidarin Contamin, Bénédicte Dash-Yandag, Budragchaagiin Diallo, Souleymane Eap, Tekchheng Endtz, Hubert Hoffmann, Jonathan Messaoudi, Melina Pandey, Nitin Pape, Jean-William Robinson, Annick Rouzier, Vanessa Russomando, Graciela Sanghvi, Sonali Sylla, Maryam Telles, Jean-Noël Siqueira, Marilda Sanchez Picot, Valentina
source	Medline; PMC
abstract	BACKGROUND: Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. METHODS/DESIGN: A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. DISCUSSION: This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0635-8) contains supplementary material, which is available to authorized users.
has issue date	2014-12-10(xsd:dateTime)
bibo:doi	10.1186/s12879-014-0635-8
bibo:pmid	25927410
has license	cc-by
sha1sum (hex)	374861bab555d907099146fb05867d810fca1ad1
schema:url	https://doi.org/10.1186/s12879-014-0635-8
resource representing a document's title	Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)
has PubMed Central identifier	PMC4272811
has PubMed identifier	25927410
schema:publication	BMC Infect Dis
resource representing a document's body	covid:374861bab555d907099146fb05867d810fca1ad1#body_text
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