About: The biological characteristics of SARS-CoV-2 Spike protein Pro330-Leu650

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About: The biological characteristics of SARS-CoV-2 Spike protein Pro330-Leu650 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The biological characteristics of SARS-CoV-2 Spike protein Pro330-Leu650
Creator	Zhang, Shuang Wang, Feng Wang, F Yi, Yao Yu, Peng-Cheng Zhang, S Yi, Y Bi, Sheng-Li Jia, Z-Y Jia, Zhi-Yuan Qiu, Feng Qiu, F Shen, Li-Ping Su, Q-D Su, Qiu-Dong Wu, Gui-Zhen Yin, W-J Yin, Wen-Jiao Yu, P-C Zhou, W-T Zhou, Wen-Ting Zou, Y-N Zou, Ye-Ning
Source	Elsevier; Medline; PMC
abstract	Abstract SARS-CoV-2 is the cause of the worldwide outbreak of COVID-19 that has been characterized as a pandemic by the WHO. Since the first report of COVID-19 on December 31, 2019, 179,111 cases were confirmed in 160 countries/regions with 7,426 deaths as of March 17, 2020. However, there have been no vaccines approved in the world to date. In this study, we analyzed the biological characteristics of the SARS-CoV-2 Spike protein, Pro330-Leu650 (SARS-CoV-2-SPL), using biostatistical methods. SARS-CoV-2-SPL possesses a receptor-binding region (RBD) and important B (Ser438-Gln506, Thr553-Glu583, Gly404-Aps427, Thr345-Ala352, and Lys529-Lys535) and T (9 CD4 and 11 CD8 T cell antigenic determinants) cell epitopes. High homology in this region between SARS-CoV-2 and SARS-CoV amounted to 87.7%, after taking the biological similarity of the amino acids into account and eliminating the receptor-binding motif (RBM). The overall topology indicated that the complete structure of SARS-CoV-2-SPL was with RBM as the head, and RBD as the trunk and the tail region. SARS-CoV-2-SPL was found to have the potential to elicit effective B and T cell responses. Our findings may provide meaningful guidance for SARS-CoV-2 vaccine design.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2020.04.070
bibo:pmid	32513514
has license	els-covid
sha1sum (hex)	375172cc6fbd8e34c8b90b8f40d66ff7b800a5cb
schema:url	https://doi.org/10.1016/j.vaccine.2020.04.070
resource representing a document's title	The biological characteristics of SARS-CoV-2 Spike protein Pro330-Leu650
has PubMed Central identifier	PMC7190498
has PubMed identifier	32513514
schema:publication	Vaccine
resource representing a document's body	covid:375172cc6fbd8e34c8b90b8f40d66ff7b800a5cb#body_text
is schema:about of	named entity 'SPL' named entity 'antigenic determinants' named entity 'SPL' named entity 'December' named entity 'SARS-CoV' named entity 'Vaccine' named entity 'T cell' named entity 'motif' named entity 'amino acids' named entity 'SARS-CoV-2' named entity 'region' named entity 'SPL' named entity 'CD8 T cell' named entity 'receptor' named entity 'SARS-CoV-2' named entity 'SPL' named entity 'binding motif' named entity 'amino acids' named entity 'antigenic determinants' named entity 'binding region' named entity 'SARS-CoV-2' named entity 'vaccine design' named entity 'vaccines' named entity 'SPL' named entity 'CD8 T cell' named entity 'SARS-CoV-2' named entity 'SPL' named entity 'vaccine design' named entity 'epitopes' named entity 'SPL' named entity 'SARS-CoV' named entity 'SARS-CoV-2' named entity 'mice' named entity 'epitopes' named entity 'epitopes' named entity 'amino acid' named entity 'epitopes' named entity 'receptor' named entity 'SPL' named entity 'Asp' named entity 'CD8 T cell' named entity 'epitopes' named entity 'coronavirus' named entity 'one-to-one correspondence' named entity 'neutralizing antibodies' named entity 'CD4' named entity 'CD4' named entity 'goldfish' named entity 'SARS-CoV' named entity 'epitopes' named entity 'RMB' named entity 'antigenic' named entity 'peptide sequences' named entity 'binding motif' named entity 'amino acid' named entity 'SARS-CoV-2' named entity 'CD8 T cell' named entity 'peptide sequences' named entity 'SPL'

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