About: Encephalomalacic Lesions in Pigs Dually Infected with Porcine Reproductive and Respiratory Syndrome Virus and Pseudorabies Virus

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About: Encephalomalacic Lesions in Pigs Dually Infected with Porcine Reproductive and Respiratory Syndrome Virus and Pseudorabies Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Encephalomalacic Lesions in Pigs Dually Infected with Porcine Reproductive and Respiratory Syndrome Virus and Pseudorabies Virus
Creator	Narita, M Ishii, M
Source	Elsevier; Medline; PMC
abstract	Abstract Four pigs (group 1) were infected with an aerosol containing porcine reproductive and respiratory syndrome virus (PRRSV) followed 7 days later by pseudorabies virus (PRV). Three further pigs (group 2) received PRRSV alone, two (group 3) received PRV alone, and two (group 4) remained as uninfected controls. Despite the admittedly small numbers of animals, the experiment appeared to throw light on aspects of synergy. Thus, the group 1 pigs showed severe neurological signs characterized by ataxia and muscular tremors. Total cell numbers in the bronchoalveolar lavage fluid were increased in all PRRSV-infected pigs, and PRRSV antigen was detected in the alveolar macrophages. Total cell numbers in the cerebrospinal fluid of group 1 pigs were considerably greater than those demonstrated in group 3, but no PRV antigen was found. Pigs of groups 1 and 2 showed pulmonary lesions, characterized by interstitial pneumonia and PRRSV antigen immunolabelling. Non-suppurative encephalitis was found in five of the six pigs of groups 1 and 3. In particular, one group 1 animal had severe necrotizing encephalitis with intranuclear inclusion bodies and associated immunolabelling of PRV antigen. The other three group 1 pigs had prominent malacic lesions, with macrophages. These neuropathological findings strongly suggested that PRRSV infection in pigs enhances the severity of brain lesions caused PRV.
has issue date	2004-11-30(xsd:dateTime)
bibo:doi	10.1016/j.jcpa.2004.05.001
bibo:pmid	15511536
has license	els-covid
sha1sum (hex)	37ba2c66c1e4cd7256ee049c8703b9d68ba442db
schema:url	https://doi.org/10.1016/j.jcpa.2004.05.001
resource representing a document's title	Encephalomalacic Lesions in Pigs Dually Infected with Porcine Reproductive and Respiratory Syndrome Virus and Pseudorabies Virus
has PubMed Central identifier	PMC7127378
has PubMed identifier	15511536
schema:publication	Journal of Comparative Pathology
resource representing a document's body	covid:37ba2c66c1e4cd7256ee049c8703b9d68ba442db#body_text
is schema:about of	named entity 'neurological' named entity 'cell' named entity 'Despite' named entity 'virus' named entity 'respiratory' named entity 'pigs' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'INCREASED' named entity 'SUPPURATIVE ENCEPHALITIS' named entity 'EXPERIMENT' named entity 'CHARACTERIZED' named entity 'NON-' named entity 'GROUP 1' named entity 'ATAXIA' named entity 'PIGS' named entity 'FINDINGS' named entity 'INFECTED' named entity 'PRV' named entity 'MUSCULAR' named entity 'DETECTED' named entity 'TREMORS' named entity 'NEUROLOGICAL' named entity 'ASSOCIATED' named entity 'PULMONARY' named entity 'INFECTION' named entity 'PSEUDORABIES VIRUS' named entity 'AEROSOL' named entity 'SYNERGY' named entity 'PSEUDORABIES VIRUS' named entity 'INFECTED' named entity 'ANTIGEN' named entity 'TOTAL' covid:arg/37ba2c66c1e4cd7256ee049c8703b9d68ba442db named entity 'BUT' named entity 'CELL' named entity 'ENCEPHALITIS' named entity 'LATER' named entity 'BRAIN LESIONS' named entity 'PROMINENT' named entity 'THESE' named entity 'FOLLOWED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'CAUSED' named entity 'NECROTIZING' named entity 'PIGS' named entity 'SEVERE' named entity 'SMALL' named entity 'CEREBROSPINAL FLUID' named entity 'DAYS' named entity 'ALVEOLAR MACROPHAGES' named entity 'INTRANUCLEAR INCLUSION BODIES' named entity 'PARTICULAR' named entity 'MACROPHAGES' named entity 'SEVERITY' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'LIGHT' named entity 'FOUND' named entity 'NUMBERS' named entity 'GROUP 3' named entity 'ANIMAL' named entity 'LESIONS' named entity 'LESIONS' named entity 'GREATER THAN' named entity 'SIGNS' named entity 'DEMONSTRATED' named entity 'THROW' named entity 'UNINFECTED' named entity 'INTERSTITIAL PNEUMONIA' named entity 'GROUPS' named entity 'CONTAINING' named entity 'ANIMALS' named entity 'RECEIVED' named entity 'pigs' named entity 'PRV' named entity 'Four' named entity 'macrophages' named entity 'antigen' named entity 'pigs' named entity 'received' named entity 'animal'

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