About: Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in Humans

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in Humans
Creator	Desforges, Marc Le Coupanec, Alain Meessen-Pinard, Mathieu Talbot, Pierre Brison, Élodie Talbot, P Brison, Á Desforges, M Le Coupanec, Á Meessen-Pinard, Á
Source	Medline; PMC
abstract	In humans, viral infections of the respiratory tract are a leading cause of morbidity and mortality worldwide. Several recognized respiratory viral agents have a neuroinvasive capacity since they can spread from the respiratory tract to the central nervous system (CNS). Once there, infection of CNS cells (neurotropism) could lead to human health problems, such as encephalitis and long-term neurological diseases. Among the various respiratory viruses, coronaviruses are important pathogens of humans and animals. Human Coronaviruses (HCoV) usually infect the upper respiratory tract, where they are mainly associated with common colds. However, in more vulnerable populations, such as newborns, infants, the elderly, and immune-compromised individuals, they can also affect the lower respiratory tract, leading to pneumonia, exacerbations of asthma, respiratory distress syndrome, or even severe acute respiratory syndrome (SARS). The respiratory involvement of HCoV has been clearly established since the 1960s. In addition, for almost three decades now, the scientific literature has also demonstrated that HCoV are neuroinvasive and neurotropic and could induce an overactivation of the immune system, in part by participating in the activation of autoreactive immune cells that could be associated with autoimmunity in susceptible individuals. Furthermore, it was shown that in the murine CNS, neurons are the main target of infection, which causes these essential cells to undergo degeneration and eventually die by some form of programmed cell death after virus infection. Moreover, it appears that the viral surface glycoprotein (S) represents an important factor in the neurodegenerative process. Given all these properties, it has been suggested that these recognized human respiratory pathogens could be associated with the triggering or the exacerbation of neurological diseases for which the etiology remains unknown or poorly understood.
has issue date	2014-03-12(xsd:dateTime)
bibo:doi	10.1007/978-81-322-1777-0_6
bibo:pmid	24619619
has license	no-cc
sha1sum (hex)	380de4234933acbebfc25ba9d91f5dc147cd2f66
schema:url	https://doi.org/10.1007/978-81-322-1777-0_6
resource representing a document's title	Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in Humans
has PubMed Central identifier	PMC7121612
has PubMed identifier	24619619
schema:publication	Infectious Diseases and Nanomedicine I
resource representing a document's body	covid:380de4234933acbebfc25ba9d91f5dc147cd2f66#body_text
is schema:about of	named entity 'neurological diseases' named entity 'encephalitis' named entity 'murine' named entity 'neurons' named entity 'addition' named entity 'humans' named entity 'AFFECT' named entity 'CNS' named entity 'ACTIVATION' named entity 'LEADING' named entity 'INDIA' named entity 'CAPACITY' named entity 'TRIGGERING' named entity 'MAIN' named entity 'RESPIRATORY VIRUSES' named entity 'NEWBORNS' named entity 'ASSOCIATED WITH' named entity 'CELLS' named entity 'PNEUMONIA' named entity 'MURINE' named entity 'DEMONSTRATED' named entity 'UNDERSTOOD' named entity 'LOWER RESPIRATORY TRACT' named entity 'ETIOLOGY' named entity 'INFECTIOUS DISEASES' named entity 'DISEASES' named entity 'ELDERLY' named entity 'IMPORTANT' named entity 'FACTOR' named entity 'LONG-TERM' named entity 'UPPER RESPIRATORY TRACT' named entity 'INFANTS' named entity 'NANOMEDICINE' named entity 'ESSENTIAL' named entity 'VARIOUS' named entity 'HUMAN HEALTH' named entity 'ADDITION' named entity 'ANIMALS' named entity 'DEGENERATION' named entity 'IMMUNE SYSTEM' named entity 'ENCEPHALITIS' named entity 'SCIENTIFIC LITERATURE' named entity 'SUSCEPTIBLE' named entity 'TARGET' named entity 'COULD BE' named entity 'INDIVIDUALS' named entity 'IMMUNE' named entity 'HUMANS' named entity 'RESPIRATORY TRACT' named entity 'ESTABLISHED' named entity 'ALMOST' named entity 'FORM' named entity 'CAUSE' named entity 'NEURODEGENERATIVE PROCESS' named entity 'USUALLY' named entity 'WORLDWIDE' named entity 'RESPIRATORY' named entity 'MORBIDITY AND MORTALITY' named entity 'PROBLEMS' named entity 'COMMON COLDS' named entity 'NEURONS' named entity 'ASTHMA' named entity 'SPRINGER' named entity 'HAVE' named entity 'CORONAVIRUSES' named entity 'PATHOGENS' named entity 'THESE' named entity 'NEUROTROPIC' named entity 'PROGRAMMED CELL DEATH' named entity 'INDUCE' named entity 'INVOLVEMENT' named entity 'HUMAN'

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