About: P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

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About: P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus
Creator	Chen, Yu Zhang, Zhen Ji, Yanxi Cao, Liu Guo, Shuting Guo, Xiaolong Li, Chun-Mei Liu, Qianyun Tong, Yongjia Zeng, Lanyi Guoid, Deyin Zhaoid, Xiaolu
Source	Medline; PMC
abstract	Interferon-inducible p200 family protein IFI204 was reported to be involved in DNA sensing, and subsequently induces the production of type I interferons and proinflammatory mediators. However, its function in the regulation of antiviral innate immune signaling pathway remains unclear. Here we reported a novel role of IFI204 that specifically inhibits the IRF7-mediated type I interferons response during viral infection. IFI204 and other p200 family proteins are highly expressed in mouse hepatitis coronavirus-infected bone marrow-derived dendritic cells. The abundant IFI204 could significantly interact with IRF7 in nucleus by its HIN domain and prevent the binding of IRF7 with its corresponding promoter. Moreover, other p200 family proteins that possess HIN domain could also inhibit the IRF7-mediated type I interferons. These results reveal that, besides the positive regulation function in type I interferon response at the early stage of DNA virus infection, the interferon-inducible p200 family proteins such as IFI204 could also negatively regulate the IRF7-mediated type I interferon response after RNA virus infection to avoid unnecessary host damage from hyper-inflammatory responses.
has issue date	2019-10-11(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1008079
bibo:pmid	31603949
has license	cc-by
sha1sum (hex)	3819c9d30c75527e915470a797c69fa83934fa06
schema:url	https://doi.org/10.1371/journal.ppat.1008079
resource representing a document's title	P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus
has PubMed Central identifier	PMC6818788
has PubMed identifier	31603949
schema:publication	PLoS Pathog
resource representing a document's body	covid:3819c9d30c75527e915470a797c69fa83934fa06#body_text
is schema:about of	named entity 'early' named entity 'response' named entity 'type I interferons' named entity 'family' named entity 'DNA virus' named entity 'p200' named entity 'mouse' named entity 'VIRUS INFECTION' named entity 'P200' named entity 'DOMAIN' named entity 'MEDIATORS' named entity 'MEDIATED' named entity 'REGULATE' named entity 'RNA VIRUS' named entity 'PROTEIN ' named entity 'EXPRESSED' named entity 'SIGNALING PATHWAY' named entity 'ROLE' named entity 'TYPE I INTERFERONS' named entity 'EARLY STAGE' named entity 'VIRAL INFECTION' named entity 'ITS' named entity 'RESPONSE' named entity 'P200' named entity 'IMMUNE' named entity 'INFECTED' named entity 'BONE MARROW' named entity 'NUCLEUS' named entity 'TO AVOID' named entity 'INTERACT' named entity 'TARGETING' named entity 'REVEAL' named entity 'DNA' named entity 'FAMILY' named entity 'UNCLEAR' named entity 'INTERFERON ' named entity 'NUCLEUS' named entity 'DENDRITIC CELLS' named entity 'REPORTED' named entity 'IFI204' named entity 'IRF7' named entity 'PROTEIN ' named entity 'THESE' named entity 'INDUCIBLE' named entity 'BINDING' named entity 'IFI204' named entity 'POSSESS' named entity 'HIN' named entity 'HERE' named entity 'ANTIVIRAL' named entity 'PROTEINS' named entity 'CORONAVIRUS' named entity 'FAMILY' named entity 'NOVEL' named entity 'IRF7' named entity 'INVOLVED' named entity 'POSITIVE REGULATION' named entity 'RESULTS' named entity 'TYPE I INTERFERON' named entity 'RESPONSES' named entity 'DAMAGE' named entity 'PROMOTER' named entity 'PRODUCTION' named entity 'RESPONSES' named entity 'DERIVED' named entity 'PREVENT' named entity 'ABUNDANT' named entity 'TYPE I INTERFERON' named entity 'MOUSE HEPATITIS' named entity 'FUNCTION'

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