About: Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression()

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About: Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression()
Creator	Huang, Ian Lim, Michael Pranata, Raymond Anthonius, Michael
Source	Elsevier; Medline; PMC; WHO
abstract	BACKGROUND AND AIMS: Diabetes Mellitus (DM) is chronic conditions with devastating multi-systemic complication and may be associated with severe form of Coronavirus Disease 2019 (COVID-19). We conducted a systematic review and meta-analysis in order to investigate the association between DM and poor outcome in patients with COVID-19 pneumonia. METHODS: Systematic literature search was performed from several electronic databases on subjects that assess DM and outcome in COVID-19 pneumonia. The outcome of interest was composite poor outcome, including mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care unit (ICU) care, and disease progression. RESULTS: There were a total of 6452 patients from 30 studies. Meta-analysis showed that DM was associated with composite poor outcome (RR 2.38 [1.88, 3.03], p < 0.001; I(2): 62%) and its subgroup which comprised of mortality (RR 2.12 [1.44, 3.11], p < 0.001; I(2): 72%), severe COVID-19 (RR 2.45 [1.79, 3.35], p < 0.001; I(2): 45%), ARDS (RR 4.64 [1.86, 11.58], p = 0.001; I(2): 9%), and disease progression (RR 3.31 [1.08, 10.14], p = 0.04; I(2): 0%). Meta-regression showed that the association with composite poor outcome was influenced by age (p = 0.003) and hypertension (p < 0.001). Subgroup analysis showed that the association was weaker in studies with median age ≥55 years-old (RR 1.92) compared to <55 years-old (RR 3.48), and in prevalence of hypertension ≥25% (RR 1.93) compared to <25% (RR 3.06). Subgroup analysis on median age <55 years-old and prevalence of hypertension <25% showed strong association (RR 3.33) CONCLUSION: DM was associated with mortality, severe COVID-19, ARDS, and disease progression in patients with COVID-19.
has issue date	2020-04-17(xsd:dateTime)
bibo:doi	10.1016/j.dsx.2020.04.018
bibo:pmid	32334395
has license	no-cc
sha1sum (hex)	3822c44cca09ac0c8c9be51a6686f3b17924b600
schema:url	https://doi.org/10.1016/j.dsx.2020.04.018
resource representing a document's title	Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression()
has PubMed Central identifier	PMC7162793
has PubMed identifier	32334395
schema:publication	Diabetes Metab Syndr
resource representing a document's body	covid:3822c44cca09ac0c8c9be51a6686f3b17924b600#body_text
is schema:about of	named entity 'Title' named entity 'Meta-analysis' named entity 'TO INVESTIGATE' named entity 'SEVERE' named entity 'ASSOCIATION' covid:arg/3822c44cca09ac0c8c9be51a6686f3b17924b600 named entity 'complication' named entity '2019' named entity 'Coronavirus' named entity 'Diabetes' named entity 'Short' named entity 'chronic conditions' named entity 'COVID' named entity 'Diabetes Mellitus' named entity 'Meta-analysis' named entity 'Systematic Review' named entity 'COVID-19' named entity 'Diabetes' named entity 'COPD' named entity 'Subgroup analysis' named entity 'ARDS' named entity 'diabetic' named entity 'ACE2' named entity 'SARI' named entity 'COVID' named entity 'hypertension' named entity 'clinical significance' named entity 'infection' named entity 'comorbidity' named entity 'C-reactive protein' named entity 'risk factor' named entity 'prognosis' named entity 'Severe Acute Respiratory Syndrome' named entity 'D-dimer' named entity 'hyperglycaemia' named entity 'World Health Organization' named entity 'COPD' named entity 'ARDS' named entity 'antioxidant' named entity 'Stata' named entity 'ACEI' named entity 'older age' named entity 'ICU' named entity 'interleukin (IL)-6' named entity 'COVID-19' named entity 'COVID' named entity 'ACEI' named entity 'COVID' named entity 'animal model' named entity 'Data extraction' named entity 'innate immunity' named entity 'oxygen saturation' named entity 'Diabetic patients' named entity 'renin-angiotensin' named entity 'systematic review' named entity 'China' named entity 'COVID' named entity 'enzyme' named entity 'IL-6' named entity '3, 4' named entity 'diabetic patients' named entity 'hypertension' named entity 'mmHg' named entity 'angiotensin II' named entity 'ACEI' named entity 'mortality rate' named entity 'ARDS' named entity 'inclusion and exclusion criteria' named entity 'cardiovascular diseases' named entity 'ARDS' named entity 'hypertension' named entity 'ACE2' named entity 'hypertension' named entity 'oxygen' named entity 'COVID' named entity 'COVID' named entity 'COVID' named entity 'study design'

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