About: Differential Ventilation Using Flow Control Valves as a Potential Bridge to Full Ventilatory Support during the COVID-19 Crisis: From Bench to Bedside

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About: Differential Ventilation Using Flow Control Valves as a Potential Bridge to Full Ventilatory Support during the COVID-19 Crisis: From Bench to Bedside Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Differential Ventilation Using Flow Control Valves as a Potential Bridge to Full Ventilatory Support during the COVID-19 Crisis: From Bench to Bedside
Creator	Park, Chang Burnett, Garrett Chen, Martin Kane, Erica Katz, Daniel Levin, Matthew Ranginwala, Shams Shah, Ronak Shah, Anjan Zhou, George Costa, Anthony
source	Medline; PMC
abstract	During the COVID-19 pandemic, ventilator sharing was suggested to increase availability of mechanical ventilation. The safety and feasibility of ventilator sharing is unknown. METHODS: A single ventilator in pressure control mode was used with flow control valves to simultaneously ventilate two patients with different lung compliances. The system was first evaluated using high-fidelity human patient simulator mannequins and then tested for 1 h in two pairs of COVID-19 patients with acute respiratory failure. Patients were matched on positive end-expiratory pressure, fractional inspired oxygen tension, and respiratory rate. Tidal volume and peak airway pressure (P(MAX)) were recorded from each patient using separate independent spirometers and arterial blood gas samples drawn at 0, 30, and 60 min. The authors assessed acid-base status, oxygenation, tidal volume, and P(MAX) for each patient. Stability was assessed by calculating the coefficient of variation. RESULTS: The valves performed as expected in simulation, providing a stable tidal volume of 400 ml each to two mannequins with compliance ratios varying from 20:20 to 20:90 ml/cm H(2)O. The system was then tested in two pairs of patients. Pair 1 was a 49-yr-old woman, ideal body weight 46 kg, and a 55-yr-old man, ideal body weight 64 kg, with lung compliance 27 ml/cm H(2)O versus 35 ml/cm H(2)O. The coefficient of variation for tidal volume was 0.2 to 1.7%, and for P(MAX) 0 to 1.1%. Pair 2 was a 32-yr-old man, ideal body weight 62 kg, and a 56-yr-old woman, ideal body weight 46 kg, with lung compliance 12 ml/cm H(2)O versus 21 ml/cm H(2)O. The coefficient of variation for tidal volume was 0.4 to 5.6%, and for P(MAX) 0 to 2.1%. CONCLUSIONS: Differential ventilation using a single ventilator is feasible. Flow control valves enable delivery of stable tidal volume and P(MAX) similar to those provided by individual ventilators.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.1097/aln.0000000000003473
bibo:pmid	32639236
has license	no-cc
sha1sum (hex)	382a589fde8430e0ff799559d16987f287e0dfd6
schema:url	https://doi.org/10.1097/aln.0000000000003473
resource representing a document's title	Differential Ventilation Using Flow Control Valves as a Potential Bridge to Full Ventilatory Support during the COVID-19 Crisis: From Bench to Bedside
has PubMed Central identifier	PMC7359901
has PubMed identifier	32639236
schema:publication	Anesthesiology
resource representing a document's body	covid:382a589fde8430e0ff799559d16987f287e0dfd6#body_text
is schema:about of	named entity 'Ventilator' named entity 'PDF' named entity 'Version 2.0' named entity 'PEEP' named entity 'tidal volume' named entity 'sensor' named entity 'ventilator' named entity 'spirometry' named entity 'Electrical tape' named entity 'tidal volume' named entity 'end tidal' named entity 'ventilator' named entity 'blood pressure' named entity 'ventilator' named entity 'clean circuit' named entity 'sensor' named entity 'spirometry' named entity 'ventilator' named entity 'PEEP' named entity 'GitHub' named entity 'EtCO' named entity 'PEEP' named entity 'PEEP' named entity 'ventilator' named entity 'ideal body weight' named entity 'hydrogen peroxide' named entity '3D printed' named entity 'spirometry' named entity 'tidal volume' named entity 'spirometry' named entity 'CDC' named entity 'arterial blood gas' named entity 'PEEP' named entity 'lung compliance' named entity 'ventilator' named entity 'corrosion' named entity 'EtCO' named entity 'ventilator' named entity 'tidal volume' named entity 'tidal volume' named entity 'CO2' named entity 'ventilator' named entity 'arterial blood gas' named entity 'solder' named entity 'ventilator' named entity 'One-way valve' named entity 'electrical tape' named entity 'PVC' named entity 'PVC' named entity 'check valve' named entity 'Heat and Moisture Exchanger' named entity 'TIDAL VOLUME' named entity 'ventilator' named entity 'ALARM' named entity 'PEEP' named entity 'tidal volume' named entity 'peracetic acid' named entity 'ventilator' named entity 'spirometry' named entity 'ventilator' named entity 'spirometry' named entity 'sensor' named entity 'ventilator' named entity 'minute ventilation' named entity 'tidal volume' named entity 'ventilator' named entity 'plumbing' named entity 'ABG' named entity 'ventilator' named entity 'mechanical ventilation' named entity 'ventilator'

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