About: Delivery of therapeutic oligonucleotides with cell penetrating peptides

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About: Delivery of therapeutic oligonucleotides with cell penetrating peptides Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Delivery of therapeutic oligonucleotides with cell penetrating peptides
Creator	Lebleu, Bernard Betts, Corinne Godfrey, Caroline Boisguérin, Prisca Deshayes, Sébastien Gait, Michael Wood, Matthew O'donovan, Liz
Source	Elsevier; Medline; PMC
abstract	Abstract Oligonucleotide-based drugs have received considerable attention for their capacity to modulate gene expression very specifically and as a consequence they have found applications in the treatment of many human acquired or genetic diseases. Clinical translation has been often hampered by poor biodistribution, however. Cell-penetrating peptides (CPPs) appear as a possibility to increase the cellular delivery of non-permeant biomolecules such as nucleic acids. This review focuses on CPP-delivery of several classes of oligonucleotides (ONs), namely antisense oligonucleotides, splice switching oligonucleotides (SSOs) and siRNAs. Two main strategies have been used to transport ONs with CPPs: covalent conjugation (which is more appropriate for charge-neutral ON analogues) and non-covalent complexation (which has been used for siRNA delivery essentially). Chemical synthesis, mechanisms of cellular internalization and various applications will be reviewed. A comprehensive coverage of the enormous amount of published data was not possible. Instead, emphasis has been put on strategies that have proven to be effective in animal models of important human diseases and on examples taken from the authors' own expertise.
has issue date	2015-06-29(xsd:dateTime)
bibo:doi	10.1016/j.addr.2015.02.008
bibo:pmid	25747758
has license	els-covid
sha1sum (hex)	3883b3e9bec22a13be60193180b05c107c63cdf0
schema:url	https://doi.org/10.1016/j.addr.2015.02.008
resource representing a document's title	Delivery of therapeutic oligonucleotides with cell penetrating peptides
has PubMed Central identifier	PMC7102600
has PubMed identifier	25747758
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:3883b3e9bec22a13be60193180b05c107c63cdf0#body_text
is schema:about of	named entity 'transport' named entity 'essentially' named entity 'applications' named entity 'TREATMENT' named entity 'SIRNAS' named entity 'RECEIVED' named entity 'TO INCREASE' named entity 'BIODISTRIBUTION' named entity 'NON-' named entity 'GENETIC DISEASES' named entity 'OLIGONUCLEOTIDES' named entity 'SIRNA DELIVERY' named entity 'APPEAR' named entity 'ANTISENSE OLIGONUCLEOTIDES' named entity 'SWITCHING' named entity 'TO TRANSPORT' named entity 'APPROPRIATE' named entity 'PROVEN' named entity 'INTERNALIZATION' named entity 'STRATEGIES' named entity 'BIOMOLECULES' named entity 'MECHANISMS' named entity 'POSSIBLE' named entity 'THEIR' named entity 'ONS' named entity 'OLIGONUCLEOTIDE' named entity 'TAKEN' named entity 'EFFECTIVE' named entity 'GENE EXPRESSION' named entity 'HAVE' named entity 'AUTHORS' named entity 'HUMAN DISEASES' named entity 'CONSIDERABLE' named entity 'NUCLEIC ACIDS' named entity 'VARIOUS' named entity 'PEPTIDES' named entity 'THERAPEUTIC' named entity 'MAIN' named entity 'BASED' named entity 'COMPREHENSIVE' named entity 'ANIMAL MODELS ' named entity 'CLASSES' named entity 'CHARGE' named entity 'EXPERTISE' named entity 'CELLULAR' named entity 'CELL' named entity 'HUMAN' named entity 'USED' named entity 'COVALENT' named entity 'FOUND' named entity 'IMPORTANT' named entity 'SPLICE' named entity 'PENETRATING' named entity 'DELIVERY' named entity 'OLIGONUCLEOTIDES' named entity 'CHEMICAL SYNTHESIS' named entity 'APPLICATIONS' named entity 'DRUGS' named entity 'DELIVERY' named entity 'NEUTRAL' named entity 'COVERAGE' named entity 'COVALENT CONJUGATION' named entity 'CAPACITY' named entity 'REVIEWED' named entity 'CONSEQUENCE' named entity 'PUBLISHED' named entity 'TRANSLATION' named entity 'ATTENTION' named entity 'POSSIBILITY' named entity 'CELL-PENETRATING PEPTIDES' named entity 'CPP' named entity 'DATA' named entity 'CLINICAL' named entity 'MODULATE'

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