About: Aminopeptidase N (CD13) functionally interacts with FcγRs in human monocytes

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About: Aminopeptidase N (CD13) functionally interacts with FcγRs in human monocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aminopeptidase N (CD13) functionally interacts with FcγRs in human monocytes
Creator	Ortega, Enrique Mina-Osorio, Paola
Source	Medline; PMC
abstract	Aminopeptidase N (E.C. 3.4.11.2) is a membrane‐bound metalloproteinase expressed in many tissues. Although its cytoplasmic portion has only eight amino acids, cross‐linking of CD13 by monoclonal antibodies (mAb) has been shown to trigger intracellular signaling. A functional association between CD13 and receptors for immunoglobulin G (FcγRs) has been proposed. In this work, we evaluated possible functional interactions between CD13 and FcγRs in human peripheral blood monocytes and in U‐937 promonocytic cells. Our results show that during FcγR‐mediated phagocytosis, CD13 redistributes to the phagocytic cup and is internalized into the phagosomes. Moreover, modified erythrocytes that interact with the monocytic cell membrane through FcγRI and CD13 are ingested simultaneously, more efficiently than those that interact through the FcγRI only. Also, co‐cross‐linking of CD13 with FcγRI by specific mAbs increases the level and duration of Syk phosphorylation induced by FcγRI cross‐linking. Finally, FcγRI and CD13 colocalize in zones of cellular polarization and coredistribute after aggregation of either of them. These results demonstrate that CD13 and FcγRI can functionally interact on the monocytic cell membrane and suggest that CD13 may act as a signal regulator of FcγR function.
has issue date	2005-03-09(xsd:dateTime)
bibo:doi	10.1189/jlb.1204714
bibo:pmid	15758076
has license	no-cc
sha1sum (hex)	38a325a5a9cf26495daf81eca0acb09acfc2dd50
schema:url	https://doi.org/10.1189/jlb.1204714
resource representing a document's title	Aminopeptidase N (CD13) functionally interacts with FcγRs in human monocytes
has PubMed Central identifier	PMC7167080
has PubMed identifier	15758076
schema:publication	J Leukoc Biol
resource representing a document's body	covid:38a325a5a9cf26495daf81eca0acb09acfc2dd50#body_text
is schema:about of	named entity 'expressed' named entity 'metalloproteinase' named entity 'monocytes' named entity 'functionally' named entity 'INGESTED' named entity 'THESE' named entity 'IMMUNOGLOBULIN G' named entity 'PHOSPHORYLATION' named entity '3.4.11.2' named entity 'BLOOD MONOCYTES' named entity 'FUNCTIONAL' named entity 'INCREASES' named entity 'AGGREGATION' named entity 'CELLULAR' named entity 'level' named entity 'mAbs' named entity 'monocytic' named entity 'Aminopeptidase N' named entity 'monocytic' named entity 'cross-linking' named entity 'intracellular signaling' named entity 'monocytic' named entity 'CD13' named entity 'mAbs' named entity 'Aminopeptidase' named entity 'cell membrane' named entity 'CD13' named entity 'membrane-bound' named entity 'monocytes' named entity 'physiological' named entity 'streptomycin' named entity 'flow cytometry' named entity 'DABCO' named entity 'signal-transducing' named entity 'hypotonic' named entity 'cytolysis' named entity 'immunocomplexes' named entity 'coronavirus' named entity 'opsonized' named entity 'kidney' named entity 'secondary antibody' named entity 'phosphorylated' named entity 'IgG' named entity 'CD13' named entity 'Syk' named entity 'phagocytic' named entity 'human coronavirus' named entity 'IgG' named entity 'liver' named entity '37°C' named entity 'staining' named entity 'IgG1' named entity 'polyacrylamide gel electrophoresis' named entity 'Molecular Probes' named entity 'peripheral blood' named entity 'PBS' named entity 'toxin' named entity 'opsonized' named entity 'FITC' named entity 'CD13' named entity 'CD13' named entity 'opsonized' named entity 'PBS' named entity 'erythrocytes' named entity 'sodium' named entity 'Santa Cruz Biotechnology' named entity 'CD13' named entity 'tyrosine kinases' named entity 'peptides' named entity 'sodium azide' named entity 'opsonized' named entity '37°C' named entity 'phagocytic' named entity 'Bio-Rad' named entity 'nonessential amino acid' named entity 'small intestinal' named entity 'mAb' named entity 'Triton X-100' named entity 'streptomycin' named entity 'Phagocytosis'

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