About: Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar

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About: Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar
Creator	Heraud, Jean-Michel Goodman, Steven Jenkins, Richard Razanajatovo, Norosoa Jones, Julia Nomenjanahary, Lalaina Razafimanahaka, Julie Wilkinson, David
source	Medline; PMC
abstract	BACKGROUND: Bats are amongst the natural reservoirs of many coronaviruses (CoVs) of which some can lead to severe infection in human. African bats are known to harbor a range of pathogens (e.g., Ebola and Marburg viruses) that can infect humans and cause disease outbreaks. A recent study in South Africa isolated a genetic variant closely related to MERS-CoV from an insectivorous bat. Though Madagascar is home to 44 bat species (41 insectivorous and 3 frugivorous) of which 34 are endemic, no data exists concerning the circulation of CoVs in the island’s chiropteran fauna. Certain Malagasy bats can be frequently found in close contact with humans and frugivorous bats feed in the same trees where people collect and consume fruits and are hunted and consumed as bush meat. The purpose of our study is to detect and identify CoVs from frugivorous bats in Madagascar to evaluate the risk of human infection from infected bats. METHODS: Frugivorous bats belonging to three species were captured in four different regions of Madagascar. We analyzed fecal and throat swabs to detect the presence of virus through amplification of the RNA-dependent RNA polymerase (RdRp) gene, which is highly conserved in all known coronaviruses. Phylogenetic analyses were performed from positive specimens. RESULTS: From 351 frugivorous bats, we detected 14 coronaviruses from two endemic bats species, of which 13 viruses were identified from Pteropus rufus and one from Eidolon dupreanum, giving an overall prevalence of 4.5%. Phylogenetic analysis revealed that the Malagasy strains belong to the genus Betacoronavirus but form three distinct clusters, which seem to represent previously undescribed genetic lineages. CONCLUSIONS: Our findings suggest that CoVs circulate in frugivorous bats of Madagascar, demonstrating the needs to evaluate spillover risk to human populations especially for individuals that hunt and consume infected bats. Possible dispersal mechanisms as to how coronaviruses arrived on Madagascar are discussed.
has issue date	2015-03-12(xsd:dateTime)
bibo:doi	10.1186/s12985-015-0271-y
bibo:pmid	25888853
has license	cc-by
sha1sum (hex)	395fef2b73d1c568f900de94f5f6d908bc305f24
schema:url	https://doi.org/10.1186/s12985-015-0271-y
resource representing a document's title	Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar
has PubMed Central identifier	PMC4404003
has PubMed identifier	25888853
schema:publication	Virol J
resource representing a document's body	covid:395fef2b73d1c568f900de94f5f6d908bc305f24#body_text
is schema:about of	named entity 'bats' named entity 'viruses' named entity 'Phylogenetic analyses' named entity 'MERS-CoV' named entity 'species' named entity 'bush meat' named entity 'bats' named entity 'TO DETECT' named entity 'COLLECT' named entity 'FRUITS' named entity 'SPECIMENS' named entity 'BETACORONAVIRUSES' named entity 'GENETIC' named entity 'INFECTION' named entity 'FREQUENTLY' named entity 'RELATED' named entity 'MERS-COV' named entity 'NO DATA' named entity 'WHERE' named entity 'NATURAL' named entity 'FEED' named entity '27S' named entity 'PERFORMED' named entity 'SOUTH AFRICA' named entity 'METHODS' named entity 'HARBOR' named entity 'AMPLIFICATION' named entity 'BACKGROUND' named entity 'RANGE' named entity 'SPECIES' named entity 'KNOWN' named entity 'BATS' named entity 'ENDEMIC' named entity 'SWABS' named entity 'HIGHLY' named entity 'LEAD' named entity 'RISK OF' named entity 'REGIONS' named entity 'MADAGASCAR' named entity 'VARIANTS' named entity 'DETECTION' named entity 'MADAGASCAR' named entity 'NEW' named entity 'COVS' named entity 'THROAT' named entity 'CONTACT WITH' named entity 'EVALUATE' named entity 'STUDY' named entity 'PURPOSE' named entity 'PRESENCE OF VIRUS' named entity 'BUSH' named entity 'RESERVOIRS' named entity 'THE ISLAND' named entity 'MARBURG VIRUSES' named entity 'BATS' named entity 'CAUSE DISEASE' named entity 'PATHOGENS' named entity 'INFECTED' named entity 'EBOLA' named entity 'CIRCULATION' named entity 'FOUND' named entity 'IDENTIFY' named entity 'POSITIVE' named entity 'ENDEMIC' named entity 'CERTAIN' named entity 'ANALYZED' named entity 'DISEASE OUTBREAKS' named entity 'RECENT' named entity 'CONSERVED' named entity 'BAT' named entity 'BELONGING' named entity 'HUMANS' named entity 'CORONAVIRUSES' named entity 'FECAL'

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