About: Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease

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About: Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease
Creator	Liu, Li Bao, Ran Bian, Yongzhong Chen, Guangyu Chen, Peng Du, Hongwu Shi, Lili Sun, Shutao Tian, Yaping Wang, Xiaoxu Wang, Yajie Wen, Yongqiang Xun, Yiping Yan, Hai Yang, Chunhe Zhang, Chunyan Zhang, Huai Zhou, Yabin
Source	Medline; PMC
abstract	Cell membrane proteins are believed to play a critical role in the pathogenesis of autoimmune diseases. However, few membrane autoantigens have been linked with Behçet's disease. Here, a cell-chip was performed to identify autoantibody target cells, and the suspected autoantigens were detected using immunoblotting. The amino acid sequences of the detected proteins were determined using LC-MALDI-TOF/TOF. Putative proteins were recombinantly expressed and purified, and a corresponding ELISA was developed and clinically validated using real clinical samples. It was found that a 36-kDa membrane protein - annexin A2 - was detected in approximately one-third of the patients' blood circulation. The immunohistochemistry results showed that annexin A2 was highly expressed in vascular endothelial cells. Moreover, vascular involvement was significantly higher in the anti-annexin A2 antibody-positive group versus the anti-annexin A2 antibody-negative group among all the clinical samples analyzed, indicating that annexin A2 is a novel endothelial cell membrane antigen involved in Behçet's disease.
has issue date	2015-02-02(xsd:dateTime)
bibo:doi	10.1038/srep08162
bibo:pmid	25641213
has license	cc-by
sha1sum (hex)	396b05e6ede13dc6078ddf0eae5c14ceae695600
schema:url	https://doi.org/10.1038/srep08162
resource representing a document's title	Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease
has PubMed Central identifier	PMC4313095
has PubMed identifier	25641213
schema:publication	Sci Rep
resource representing a document's body	covid:396b05e6ede13dc6078ddf0eae5c14ceae695600#body_text
is schema:about of	named entity 'involved' named entity 'samples' named entity 'annexin A2' named entity 'amino acid' named entity 'performed' named entity 'membrane' named entity 'HIGHER' named entity 'ANNEXIN A2' named entity 'PROTEIN ' named entity 'ANTIGEN' named entity 'INDICATING' named entity 'APPROXIMATELY' named entity 'ENDOTHELIAL CELL' named entity 'A2 ANTIBODY' named entity 'HAVE' named entity 'AUTOIMMUNITY' named entity 'EXPRESSED' named entity 'PLAY' named entity 'POSITIVE' named entity 'CRITICAL' named entity 'NEGATIVE' named entity 'IMMUNOBLOTTING' named entity 'BEH' named entity 'MEMBRANE PROTEIN' named entity 'DETECTED' named entity 'A CELL' named entity 'REAL' named entity 'PERFORMED' named entity '27S' named entity 'TARGET' named entity 'AUTOANTIGEN' named entity 'DISEASE' named entity 'INVOLVEMENT' named entity 'VALIDATED' named entity 'BEH' named entity 'CELL MEMBRANE' named entity 'PATHOGENESIS' named entity 'DETERMINED' named entity 'ANALYZED' named entity 'SUBJECT' named entity 'USING' named entity 'OPEN' named entity 'PURIFIED' named entity 'BLOOD CIRCULATION' named entity 'CELL MEMBRANE PROTEINS' named entity 'ELISA' named entity 'GROUP' named entity 'FOUND' named entity 'TARGET CELLS' named entity 'IS A' named entity 'ANNEXIN A2' named entity 'AREAS' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'VASCULAR' named entity 'PROTEINS' named entity 'KDA' named entity 'TO IDENTIFY' named entity 'ENDOTHELIAL CELL' named entity 'SUSPECTED' named entity 'DISEASE' named entity 'CHIP' named entity 'SYSTEMS BIOLOGY' named entity '27S' named entity 'AUTOIMMUNE DISEASES'

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