About: Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis

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About: Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis
Creator	Labbé, André Egron, Carole Amat, Flore Aurélien Mulliez Msc, \| Bernard, Alfred Emmanuelle, \| Phd, Rochette
Source	PMC
abstract	Acute bronchiolitis is responsible for high morbidity in infants. Club cell protein 16 kDa (CC16) is a major pneumoprotein secreted by club cells of the bronchial epithelium and eliminated by the renal pathway. CC16 seems to be a biomarker of epithelial damage in asthma. However, its value as a marker of acute bronchiolitis severity and later recurrent wheezing are uncertain, especially the value of its urinary assay for this purpose. A prospective, observational, analytical study was conducted at Clermont‐Ferrand University Hospital to correlate serum CC16 level with clinical severity of bronchiolitis in hospitalized infants aged less than 1 year. We analyzed correlations between serum and urinary CC16, CC16 levels and Wainwright score, immediate morbidity due to bronchiolitis, causal viruses, and recurrent wheezing 1 year after inclusion. In 166 infants, serum CC16 did not correlate with acute bronchiolitis severity (P = .49), but urinary CC16 did (P < .001). In multivariate analysis, urinary CC16 correlated mainly with urinary retinol binding protein (RBP; r = 0.70; P < .001). The logCC16u/logRBPu ratio correlated significantly with severity (P = .02). CC16 levels were not correlated with recurrent wheezing at 1 year. Urinary CC16 could be a useful biomarker in acute bronchiolitis for specific indications. This noninvasive assay would be particularly useful in the young infant population. Several factors must be taken into account in its interpretation, mainly tubular function. Further studies are needed to assess these factors.
has issue date	2019-11-26(xsd:dateTime)
bibo:doi	10.1002/ppul.24584
bibo:pmid	31770479
has license	no-cc
sha1sum (hex)	39788a490703d4619b98c45bfb6119a170e54246
schema:url	https://doi.org/10.1002/ppul.24584
resource representing a document's title	Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis
has PubMed Central identifier	PMC7167874
has PubMed identifier	31770479
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:39788a490703d4619b98c45bfb6119a170e54246#body_text
is schema:about of	named entity 'prospective' named entity 'correlate' named entity 'Wainwright' named entity 'hospitalized' named entity 'CORRELATIONS' named entity 'CELLS' named entity 'EPITHELIAL DAMAGE' covid:arg/39788a490703d4619b98c45bfb6119a170e54246 named entity 'serum' named entity 'bronchiolitis' named entity 'protein' named entity 'epithelial' named entity 'conducted' named entity 'infants' named entity 'wheezing' named entity 'bronchiolitis' named entity 'serum' named entity 'bronchiolitis' named entity 'wheezing' named entity 'epithelial' named entity 'morbidity' named entity 'biomarker' named entity 'club cell' named entity 'wheezing' named entity 'acute bronchiolitis' named entity 'cesarean section' named entity 'acute bronchiolitis' named entity 'Statistical analyses' named entity 'syncitial' named entity 'blood sample' named entity 'oxygen therapy' named entity 'prematurity' named entity 'virus' named entity 'concentration gradient' named entity 'acute bronchiolitis' named entity 'follow-up' named entity 'anti-inflammatory' named entity 'pediatrician' named entity 'serum' named entity 'SpO2' named entity 'protein' named entity 'rhinovirus' named entity 'significant difference' named entity 'Stata' named entity 'renal function' named entity 'Statistical analysis' named entity 'chronic inflammation' named entity 'necrosis' named entity 'pediatric' named entity '2.6' named entity 'physical activity' named entity 'Acute bronchiolitis' named entity 'urine' named entity 'club cells' named entity 'bronchiolitis' named entity 'pneumothorax' named entity 'invasive mechanical ventilation' named entity 'human rhinovirus' named entity 'parenteral' named entity 'feeding difficulties' named entity 'wheezing' named entity 'inhaled corticosteroids' named entity 'Stepwise selection' named entity 'genotyping' named entity 'phospholipase A2' named entity 'epithelial barrier' named entity 'lung' named entity 'nasopharyngeal' named entity 'serum' named entity 'creatinine' named entity 'pulmonary disease' named entity '21 days' named entity 'advanced glycation endproduct' named entity 'control group' named entity 'serum levels'

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