About: Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India
Creator	Kumar, Pawan Banerjee, Arup Begum, Feroza Das, Sandeepan Kumar Banerjee, Arup Mukherjee, Debica Prakash, Prem Ray, Upasana Thagriki, Dluya Tripathi, Prakash Gandhi, Sanjay Gratuate, Post Gupta, Jalaj Haryana, Maurya Mukherjee, Begum
source	Medline; PMC
abstract	India has recently started sequencing SARS-CoV2 genome from clinical isolates. Currently only few sequences are available from three states in India. Kerala was the first state to deposit complete sequence from two isolates followed by one from Gujarat. On April 27, 2020, the first five sequences from the state of West Bengal (Eastern India) were deposited on GISAID, a global initiative for sharing avian flu data. In this study, we have analysed the spike protein sequences from all five isolates and also compared their similarities or differences with other sequences reported in India and with isolates of Wuhan origin. We report one unique mutation at position 723 and another at 1124 in the S2 domain of spike protein of the isolates from West Bengal only. There was one mutation downstream of the receptor binding domain at position 614 in S1 domain which was common with the sequence from Gujarat (a state of western India). Mutation in the S2 domain showed changes in the secondary structure of the spike protein at region of the mutation. We also studied molecular dynamics using normal mode analyses and found that this mutation decreases the flexibility of S2 domain. Since both S1 and S2 are important in receptor binding followed by entry in the host cells, such mutations may define the affinity or avidity of receptor binding.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.12688/f1000research.23805.1
bibo:pmid	32595958
has license	cc-by
sha1sum (hex)	39ce88b3cf04682df9926b15bbe9ff5e804585bb
schema:url	https://doi.org/10.12688/f1000research.23805.1
resource representing a document's title	Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India
has PubMed Central identifier	PMC7309413
has PubMed identifier	32595958
schema:publication	F1000Res
resource representing a document's body	covid:39ce88b3cf04682df9926b15bbe9ff5e804585bb#body_text
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