About: COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series
Creator	Murdaca, Giuseppe Antonelli, Alessandro Fallahi, Poupak Ferri, Clodoveo Giuggioli, Dilia Ursini, Francesco Aiello, Vincenzo Bellando-Randone, Silvia Bilia, Silvia Brittelli, Raffaele Brusi, Veronica Caminiti, Maurizio Caminiti, Rodolfo Cecchetti, Riccardo Colaci, Michele Ferrari, Tommaso Giannini, Daiana Gigliotti, Pietro Guiducci, Serena L'andolina, Massimo Meliconi, Riccardo Olivo, Domenico Pagano, Giuseppa Pellegrini, Roberta Raimondo, Vincenzo Spinella, Amelia Tavoni, Antonio Varcasia, Giuseppe
source	Medline; PMC
abstract	INTRODUCTION: Covid-19 infection poses a serious challenge for immune-compromised patients with inflammatory autoimmune systemic diseases. We investigated the clinical-epidemiological findings of 1641 autoimmune systemic disease Italian patients during the Covid-19 pandemic. METHOD: This observational multicenter study included 1641 unselected patients with autoimmune systemic diseases from three Italian geographical areas with different prevalence of Covid-19 [high in north (Emilia Romagna), medium in central (Tuscany), and low in south (Calabria)] by means of telephone 6-week survey. Covid-19 was classified as (1) definite diagnosis of Covid-19 disease: presence of symptomatic Covid-19 infection, confirmed by positive oral/nasopharyngeal swabs; (2) highly suspected Covid-19 disease: presence of highly suggestive symptoms, in absence of a swab test. RESULTS: A significantly higher prevalence of patients with definite diagnosis of Covid-19 disease, or with highly suspected Covid-19 disease, or both the conditions together, was observed in the whole autoimmune systemic disease series, compared to “Italian general population” (p = .030, p = .001, p = .000, respectively); and for definite + highly suspected diagnosis of Covid-19 disease, in patients with autoimmune systemic diseases of the three regions (p = .000, for all comparisons with the respective regional general population). Moreover, significantly higher prevalence of definite + highly suspected diagnosis of Covid-19 disease was found either in patients with various “connective tissue diseases” compared to “inflammatory arthritis group” (p < .000), or in patients without ongoing conventional synthetic disease-modifying anti-rheumatic drugs treatments (p = .011). CONCLUSIONS: The finding of a higher prevalence of Covid-19 in patients with autoimmune systemic diseases is particularly important, suggesting the need to develop valuable prevention/management strategies, and stimulates in-depth investigations to verify the possible interactions between Covid-19 infection and impaired immune-system of autoimmune systemic diseases.
has issue date	2020-08-27(xsd:dateTime)
bibo:doi	10.1007/s10067-020-05334-7
bibo:pmid	32852623
has license	cc-by
sha1sum (hex)	39cef3ec8837de1c20185006cc7a98be39135335
schema:url	https://doi.org/10.1007/s10067-020-05334-7
resource representing a document's title	COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series
has PubMed Central identifier	PMC7450255
has PubMed identifier	32852623
schema:publication	Clin Rheumatol
resource representing a document's body	covid:39cef3ec8837de1c20185006cc7a98be39135335#body_text
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