About: Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis

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About: Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis
Creator	Chen, Gang Liu, Jia Wu, Peng Li, Yuan Liu, Chen Ma, Ding Fu, Yu Yang, Bin Wu, Ping Lu, Wanrong Meng, Yifan Guo, Ensong Huang, Yuhan Li, Fuxia Lin, Shitong Lu, Funian Peng, Ting Sun, Chaoyang Wang, Zizhuo Wu, Xue Xiao, Rourou You, Lixin
Source	Medline; PMC
abstract	BACKGROUND: Although research on the effects of comorbidities on coronavirus disease 2019 (COVID-19) patients is increasing, the risk of cancer history has not been evaluated for the mortality of patients with COVID-19. METHODS: In this retrospective study, we included 3232 patients with pathogen-confirmed COVID-19 who were hospitalized between January 18th and March 27th, 2020, at Tongji Hospital in Wuhan, China. Propensity score matching was used to minimize selection bias. RESULTS: In total, 2665 patients with complete clinical outcomes were analyzed. The impacts of age, sex, and comorbidities were evaluated separately using binary logistic regression analysis. The results showed that age, sex, and cancer history are independent risk factors for mortality in hospitalized COVID-19 patients. COVID-19 patients with cancer exhibited a significant increase in mortality rate (29.4% vs. 10.2%, P < 0.0001). Furthermore, the clinical outcomes of patients with hematological malignancies were worse, with a mortality rate twice that of patients with solid tumors (50% vs. 26.1%). Importantly, cancer patients with complications had a significantly higher risk of poor outcomes. One hundred nine cancer patients were matched to noncancer controls in a 1:3 ratio by propensity score matching. After propensity score matching, the cancer patients still had a higher risk of mortality than the matched noncancer patients (odds ratio (OR) 2.98, 95% confidence interval (95% CI) 1.76–5.06). Additionally, elevations in ferritin, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, procalcitonin, prothrombin time, interleukin-2 (IL-2) receptor, and interleukin-6 (IL-6) were observed in cancer patients. CONCLUSIONS: We evaluated prognostic factors with epidemiological analysis and highlighted a higher risk of mortality for cancer patients with COVID-19. Importantly, cancer history was the only independent risk factor for COVID-19 among common comorbidities, while other comorbidities may act through other factors. Moreover, several laboratory parameters were significantly different between cancer patients and matched noncancer patients, which may indicate specific immune and inflammatory reactions in COVID-19 patients with cancer.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.1186/s13045-020-00907-0
bibo:pmid	32522278
has license	cc-by
sha1sum (hex)	39e8f5d7d686ff385acb251c88e365841b387c33
schema:url	https://doi.org/10.1186/s13045-020-00907-0
resource representing a document's title	Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis
has PubMed Central identifier	PMC7286218
has PubMed identifier	32522278
schema:publication	J Hematol Oncol
resource representing a document's body	covid:39e8f5d7d686ff385acb251c88e365841b387c33#body_text
is schema:about of	named entity 'cancer' named entity 'COVID-19' named entity 'mortality' named entity 'mortality' named entity 'coronavirus disease 2019' named entity 'risk factor' named entity 'COVID-19' named entity 'COVID' named entity 'nasopharyngeal swabs' named entity 'MERS' named entity 'coronary heart disease' named entity 'COVID-19' named entity 'hypertension' named entity 'reverse transcriptase polymerase chain reaction' named entity 'Chronic obstructive pulmonary diseases' named entity 'experimental studies' named entity 'kidney injury' named entity 'Kaplan-Meier curves' named entity 'general Chinese' named entity 'coagulation' named entity 'follow-up' named entity 'higher risk' named entity 'CHD' named entity 'Interquartile range' named entity 'infection' named entity 'meta-analysis' named entity 'significant difference' named entity 'chemotherapy' named entity 'SARS-CoV-2' named entity 'senescence' named entity 'antitumor' named entity 'coagulation' named entity 'infection' named entity 'China' named entity 'IL-2' named entity 'older age' named entity 'erythrocyte sedimentation rate' named entity 'statistically significant' named entity 'risk factor' named entity 'cytokine release syndrome' named entity 'oncogenic' named entity 'IL-2' named entity 'prothrombin time' named entity 'comorbidities' named entity 'clinical characteristics' named entity 'intensive care unit' named entity 'cytokines' named entity 'prognosis' named entity 'COVID' named entity 'prognosis' named entity 'IL-6' named entity 'upregulate' named entity 'comorbidities' named entity 'solid tumors' named entity 'immunotherapy' named entity 'age-related' named entity 'follow-up' named entity 'thromboprophylaxis' named entity 'white blood cells' named entity 'COVID'

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