About: Multi-organ Proteomic Landscape of COVID-19 Autopsies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multi-organ Proteomic Landscape of COVID-19 Autopsies
Creator	Yang, Ming Hu, Yu Liu, Wei Li, Yan Luo, Meng Li, Lu Chen, Hao Li, Xiang Yu, Jing Xiao, Qi Xu, Fei Chen, Shuo Sun, Rui Peng, Li Wu, Junhua Liang, Cai, Xue Ding, Xuan Gao, Huanhuan Ge, Weigang Guo, Tiannan Lu, Tian Qian, Liujia Ruan, Guan Su, Hua Yi, Xiao Fan, Jun Huang, Bo Luo, Danju Nie, Xiu Wang, Sihua Xia, Jiahong Xie, Mingxing Zhou, Junjie Zhu, Yi Xu, Xia Yue, Liang Zhang, Qiushi Chang, Xiaona He, Jiale Lyu, Mengge Mei, Heng Pan, Huaxiong Xiao, Guixiang Xu, Luang Xue, Zhangzhi Yuan, Chunhui Zhao, Dashi
Source	MedRxiv
abstract	The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report an in-depth multi-organ proteomic landscape of COVID-19 patient autopsy samples. By integrative analysis of proteomes of seven organs, namely lung, spleen, liver, heart, kidney, thyroid and testis, we characterized 11,394 proteins, in which 5336 were perturbed in COVID-19 patients compared to controls. Our data showed that CTSL, rather than ACE2, was significantly upregulated in the lung from COVID-19 patients. Dysregulation of protein translation, glucose metabolism, fatty acid metabolism was detected in multiple organs. Our data suggested upon SARS-CoV-2 infection, hyperinflammation might be triggered which in turn induces damage of gas exchange barrier in the lung, leading to hypoxia, angiogenesis, coagulation and fibrosis in the lung, kidney, spleen, liver, heart and thyroid. Evidence for testicular injuries included reduced Leydig cells, suppressed cholesterol biosynthesis and sperm mobility. In summary, this study depicts the multi-organ proteomic landscape of COVID-19 autopsies, and uncovered dysregulated proteins and biological processes, offering novel therapeutic clues.
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1101/2020.08.16.20176065
has license	medrxiv
sha1sum (hex)	39f3eeef5a0c8dbae029302f92357eece333164b
schema:url	https://doi.org/10.1101/2020.08.16.20176065
resource representing a document's title	Multi-organ Proteomic Landscape of COVID-19 Autopsies
resource representing a document's body	covid:39f3eeef5a0c8dbae029302f92357eece333164b#body_text
is schema:about of	named entity 'Proteomic' named entity 'Proteomic' named entity 'COVID' named entity 'lipid metabolism' named entity 'CXCL13' named entity 'PLG' named entity 'hepatic' named entity 'downregulated' named entity 'preprint' named entity 'MIB1' named entity 'liver cirrhosis' named entity 'preprint' named entity 'mRNA' named entity 'RNASE2' named entity 'liver' named entity 'COVID' named entity 'angiogenesis' named entity 'preprint' named entity 'protein expression' named entity 'blood volume' named entity 'COVID' named entity 'coagulation' named entity 'angiogenesis' named entity 'CRP' named entity 'mTOR signaling' named entity 'VCAM1' named entity 'obesity' named entity 'spleen' named entity 'COVID' named entity 'preprint' named entity 'lymphopenia' named entity 'adrenal glands' named entity 'mouse model' named entity 'spleen' named entity 'CDH11' named entity 'medRxiv' named entity 'sterol' named entity 'ligand'

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