About: Crosstalk Between Platelets and Microbial Pathogens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Crosstalk Between Platelets and Microbial Pathogens
Creator	Kapur, Rick Semple, John Li, Conglei Li, June Ni, Heyu Aliberti, Julio De Paula, Erich
Source	Medline; PMC
abstract	Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro-inflammatory and anti-inflammatory molecules, equipping platelets with immunoregulatory function in both innate and adaptive immunity. In the context of infectious diseases, platelets are involved in early detection of invading microorganisms and are actively recruited to sites of infection. Platelets exert their effects on microbial pathogens either by direct binding to eliminate or restrict dissemination, or by shaping the subsequent host immune response. Reciprocally, many invading microbial pathogens can directly or indirectly target host platelets, altering platelet count or/and function. In addition, microbial pathogens can impact the host auto- and alloimmune responses to platelet antigens in several immune-mediated diseases, such as immune thrombocytopenia, and fetal and neonatal alloimmune thrombocytopenia. In this review, we discuss the mechanisms that contribute to the bidirectional interactions between platelets and various microbial pathogens, and how these interactions hold relevant implications in the pathogenesis of many infectious diseases. The knowledge obtained from “well-studied” microbes may also help us understand the pathogenesis of emerging microbes, such as SARS-CoV-2 coronavirus.
has issue date	2020-08-07(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01962
bibo:pmid	32849656
has license	cc-by
sha1sum (hex)	3a3cf4a3748a4a19e1837a466edd11f8758c7b10
schema:url	https://doi.org/10.3389/fimmu.2020.01962
resource representing a document's title	Crosstalk Between Platelets and Microbial Pathogens
has PubMed Central identifier	PMC7426443
has PubMed identifier	32849656
schema:publication	Front Immunol
resource representing a document's body	covid:3a3cf4a3748a4a19e1837a466edd11f8758c7b10#body_text
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