About: Toxicity associated with high-dose cytosine arabinoside and total body irradiation as conditioning for allogeneic bone marrow transplantation

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About: Toxicity associated with high-dose cytosine arabinoside and total body irradiation as conditioning for allogeneic bone marrow transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Toxicity associated with high-dose cytosine arabinoside and total body irradiation as conditioning for allogeneic bone marrow transplantation
Creator	Meyers, L Miller, A Rao, P Kumar, M Graham-Pole, J Ochoa, S Saleh, A
source	PMC
abstract	Seventy-three patients with hematological cancers undergoing allogeneic bone marrow transplantation (BMT) were evaluated for event-free survival (EFS) and toxicity. All received 36 g/m(2) cytosine arabinoside (HDA) and 1200 cGy fractionated total body irradiation (TBI). We assessed the association of EFS and toxicities with the following risk factors: age, gender, diagnosis, initial relapse risk and patient–donor histocompatibility. The EFS probability is 33% at 800 days post-BMT. Twenty-six patients (36%) died of toxicity within 100 days and 14 (19%) have relapsed. EFS was inversely associated with age (P < 0.0001) and initial relapse risk (P = 0.007). The risk of pulmonary (P = 0.023) and hepatic toxicity (P = 0.011) increased with age. Diagnosis other than acute lymphoblastic leukemia (ALL) was a risk factor (P = 0.015) for graft-versus-host disease (GVHD); and fewer ALL patients died from toxicity (P = 0.014). The probability of sepsis within 100 days post-BMT correlated (P = 0.007) with initial relapse risk. We conclude: (1) the lower EFS and greater pulmonary and hepatic toxicity associated with increasing age indicate a need for less toxic regimens that maintain high antileukemic efficacy for older patients; (2) the high GVHD and sepsis rates seen in certain categories of patients indicate a need for careful definition of eligibility criteria for this still highly toxic treatment.
has issue date	1997-12-18(xsd:dateTime)
bibo:doi	10.1038/sj.bmt.1700797
bibo:pmid	9193746
has license	no-cc
sha1sum (hex)	3acaad158867a7ddaf26b24bc6c6ba51477b10cd
schema:url	https://doi.org/10.1038/sj.bmt.1700797
resource representing a document's title	Toxicity associated with high-dose cytosine arabinoside and total body irradiation as conditioning for allogeneic bone marrow transplantation
has PubMed Central identifier	PMC7091784
has PubMed identifier	9193746
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:3acaad158867a7ddaf26b24bc6c6ba51477b10cd#body_text
is schema:about of	named entity 'standard' named entity 'allogeneic bone marrow transplantation' named entity 'evaluated' named entity 'relapse' named entity 'cytosine arabinoside' named entity 'patients' named entity 'toxicity' named entity 'October' named entity 'HDA' named entity 'terms' named entity 'demonstrated' named entity 'histocompatibility' named entity 'TBI' named entity 'total body irradiation' named entity 'cytosine arabinoside' named entity 'clinical research' named entity 'irradiation' named entity 'TBI' named entity 'toxicity' named entity 'toxicity' named entity 'hematological cancers' named entity 'total body irradiation' named entity 'activity' named entity 'relapse' named entity 'ANLL' named entity 'erythema' named entity 'side-effects' named entity 'Ara-C' named entity 'toxicity' named entity '95% CI' named entity 'risk factors' named entity 'organ' named entity 'relapse' named entity 'loci' named entity 'histocompatibility' named entity 'viruses' named entity 'risk factor' named entity 'liver toxicity' named entity 'relapse' named entity 'hepatic' named entity 'toxicity' named entity 'gastrointestinal (GI) tract' named entity 'lung' named entity 'probability' named entity 'sepsis' named entity 'sepsis' named entity 'Demographic' named entity 'probability' named entity 'relapse' named entity 'Veno-occlusive disease' named entity 'lung' named entity 'remission' named entity 'adult respiratory distress syndrome' named entity 'organ' named entity 'toxicity' named entity 'relapse' named entity 'toxicity' named entity 'pulmonary hemorrhage' named entity '95% confidence interval' named entity 'myelofibrosis' named entity 'liver' named entity 'malignancy' named entity 'hepatic' named entity 'probability' named entity 'phenotypically' named entity 'hemorrhagic cystitis' named entity 'risk factor' named entity 'MUD' named entity 'GVHD' named entity 'syngeneic' named entity 'toxicity' named entity 'risk factor' named entity 'toxicity' named entity 'relapse' named entity 'organ'

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