About: Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018

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About: Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018
Creator	El-Kafrawy, Sherif Harakeh, Steve Alagaili, Abdulaziz Alsaaidi, Ghaleb Alzahrani, Abdulrahman Amor, Nabil Hassan, Ahmed Tolah, Ahmed Al Masaudi, Saad Alsaadi, Mohammed Azharid, Esam Hashemid, Anwar Mirza Id, Ahmed
source	Medline; PMC; WHO
abstract	The Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) is an endemic virus in dromedaries. Annually, Saudi Arabia imports thousands of camels from the Horn of Africa, yet the epidemiology of MERS-CoV in these animals is largely unknown. Here, MERS-CoV prevalence was compared in imported African camels and their local counterparts. A total of 1399 paired sera and nasal swabs were collected from camels between 2016 and 2018. Imported animals from Sudan (n = 829) and Djibouti (n = 328) were sampled on incoming ships at Jeddah Islamic seaport before unloading, and local camels were sampled from Jeddah (n = 242). Samples were screened for neutralizing antibodies (nAbs) and MERS-CoV viral RNA. The overall seroprevalence was 92.7% and RNA detection rate was 17.2%. Imported camels had higher seroprevalence compared to resident herds (93.8% vs 87.6%, p <0.01) in contrast to RNA detection (13.3% vs 35.5%, p <0.0001). Seroprevalence significantly increased with age (p<0.0001) and viral RNA detection rate was ~2-folds higher in camels <2-year-old compared to older animals. RNA detection was higher in males verses females (24.3% vs 12.6%, p<0.0001) but seroprevalence was similar. Concurrent positivity for viral RNA and nAbs was found in >87% of the RNA positive animals, increased with age and was sex-dependent. Importantly, reduced viral RNA load was positively correlated with nAb titers. Our data confirm the widespread of MERS-CoV in imported and domestic camels in Saudi Arabia and highlight the need for continuous active surveillance and better prevention measures. Further studies are also warranted to understand camels correlates of protection for proper vaccine development.
has issue date	2020-05-26(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0232790
bibo:pmid	32453746
has license	cc-by
sha1sum (hex)	3ae01e2017cd44fdf74597ede1ae7653651cd914
schema:url	https://doi.org/10.1371/journal.pone.0232790
resource representing a document's title	Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018
has PubMed Central identifier	PMC7250453
has PubMed identifier	32453746
schema:publication	PLoS One
resource representing a document's body	covid:3ae01e2017cd44fdf74597ede1ae7653651cd914#body_text
is schema:about of	named entity 'CONTINUOUS' named entity 'DATA' named entity 'VIRAL RNA' named entity 'ISLAMIC' named entity 'CAMELS' named entity 'UNLOADING' named entity 'RESIDENT' named entity 'SAMPLED' named entity '12.6' named entity 'ANNUALLY' named entity 'VACCINE DEVELOPMENT' named entity 'SERA' named entity 'DEPENDENT' named entity 'IMPORTED' named entity 'PROTECTION' named entity 'POSITIVE' named entity 'FOUND' named entity 'PREVALENCE' named entity 'DETECTION' named entity 'FEMALES' named entity 'STUDIES' covid:arg/3ae01e2017cd44fdf74597ede1ae7653651cd914 named entity 'viral RNA' named entity 'vaccine' named entity 'Coronavirus' named entity 'viral RNA' named entity 'Sudan' named entity 'Horn of Africa' named entity 'Jeddah' named entity 'viral RNA' named entity 'seroprevalence' named entity 'dromedary camels' named entity 'viral load' named entity 'MERS-CoV' named entity 'zoonotic transmission' named entity 'MERS-CoV' named entity 'seroprevalence' named entity 'camel' named entity 'infection' named entity 'Germany' named entity 'Sudan' named entity 'Viral shedding' named entity 'RNA extraction' named entity 'Africa' named entity 'Sudan' named entity 'Saudi Arabia' named entity 'Egypt' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'Djibouti' named entity 'viral RNA' named entity 'MERS-CoV' named entity 'OpenEpi' named entity 'RNA' named entity 'Jeddah' named entity 'correlates of protection' named entity 'population characteristics' named entity 'North America' named entity 'seroprevalence' named entity 'epidemiology' named entity 'Sudan' named entity 'dromedaries' named entity 'RNA' named entity 'viral RNA' named entity 'sterilizing' named entity 'Saudi Arabia' named entity 'prevalence rate' named entity 'seroprevalence' named entity 'MERS-CoV'

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