About: Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

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About: Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes
Creator	Ae, Yang Ae, Ji Guo, Li-Min Lin, Shan-Shan Xiu-Juan, A
source	Medline; PMC
abstract	Multiple organ damage in severe acute respiratory syndrome (SARS) patients is common; however, the pathogenesis remains controversial. This study was to determine whether the damage was correlated with expression of the SARS coronavirus receptor, angiotensin converting enzyme 2 (ACE2), in different organs, especially in the endocrine tissues of the pancreas, and to elucidate the pathogenesis of glucose intolerance in SARS patients. The effect of clinical variables on survival was estimated in 135 SARS patients who died, 385 hospitalized SARS patients who survived, and 19 patients with non-SARS pneumonia. A total of 39 SARS patients who had no previous diabetes and received no steroid treatment were compared to 39 matched healthy siblings during a 3-year follow-up period. The pattern of SARS coronavirus receptor-ACE2 proteins in different human organs was also studied. Significant elevations in oxygen saturation, serum creatinine, lactate dehydrogenase, creatine kinase MB isoenzyme, and fasting plasma glucose (FPG), but not in alanine transaminase were predictors for death. Abundant ACE2 immunostaining was found in lung, kidney, heart, and islets of pancreas, but not in hepatocytes. Twenty of the 39 followed-up patients were diabetic during hospitalization. After 3 years, only two of these patients had diabetes. Compared with their non-SARS siblings, these patients exhibited no significant differences in FPG, postprandial glucose (PPG), and insulin levels. The organ involvements of SARS correlated with organ expression of ACE2. The localization of ACE2 expression in the endocrine part of the pancreas suggests that SARS coronavirus enters islets using ACE2 as its receptor and damages islets causing acute diabetes.
has issue date	2009-03-31(xsd:dateTime)
bibo:doi	10.1007/s00592-009-0109-4
bibo:pmid	19333547
has license	no-cc
sha1sum (hex)	3b3317a36059a322aa1cbde37ad48513be38b6ab
schema:url	https://doi.org/10.1007/s00592-009-0109-4
resource representing a document's title	Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes
has PubMed Central identifier	PMC7088164
has PubMed identifier	19333547
schema:publication	Acta Diabetol
resource representing a document's body	covid:3b3317a36059a322aa1cbde37ad48513be38b6ab#body_text
is schema:about of	named entity 'endocrine' named entity 'glucose' named entity 'PPG' named entity 'creatine kinase MB' named entity 'estimated' named entity 'determine' named entity 'hospitalization' named entity 'SARS coronavirus' named entity 'RECEPTOR' named entity 'ANGIOTENSIN CONVERTING ENZYME 2' named entity 'SIGNIFICANT' named entity 'DIABETES' named entity 'GLUCOSE' named entity 'DIABETIC' named entity 'PATTERN' named entity 'COMPARED' named entity 'NON-' named entity 'PATHOGENESIS' named entity 'EXPRESSION' named entity 'PROTEINS' named entity 'OXYGEN SATURATION' named entity 'CREATINE KINASE MB ISOENZYME' named entity 'SARS' named entity 'ALANINE TRANSAMINASE' named entity 'SERUM CREATININE' named entity 'DIFFERENT' named entity 'DETERMINE' named entity '135' named entity 'DIED' named entity 'PATIENTS' named entity 'LOCALIZATION' named entity 'HEPATOCYTES' named entity 'COMMON' named entity 'YEAR' named entity 'FOLLOWED' named entity 'TOTAL' named entity 'FOLLOW-UP PERIOD' named entity 'ACUTE' named entity 'PART OF' named entity 'RECEPTOR' named entity 'INSULIN LEVELS' named entity 'HEART' named entity 'MULTIPLE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'STEROID TREATMENT' named entity 'DURING HOSPITALIZATION' named entity 'GLUCOSE INTOLERANCE' named entity 'POSTPRANDIAL' named entity 'PANCREAS' named entity 'PNEUMONIA' named entity 'THESE' named entity 'PREVIOUS' named entity 'ELEVATIONS' named entity 'KIDNEY' named entity 'STUDY' named entity 'FPG' named entity 'FASTING PLASMA GLUCOSE' named entity 'LUNG' named entity 'CORONAVIRUS RECEPTOR' named entity 'MATCHED' named entity 'EFFECT' named entity 'ABUNDANT' named entity 'SURVIVAL' named entity 'IMMUNOSTAINING' named entity 'ORGAN' named entity 'SARS CORONAVIRUS' named entity 'SARS CORONAVIRUS' named entity 'DAMAGES' named entity 'ITS' named entity 'BINDING' named entity 'CAUSES' named entity 'DIABETES' named entity 'FOUND' named entity 'BUT' named entity '385' named entity 'HUMAN' named entity 'VARIABLES'

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