About: Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia
Creator	Blasi, Francesco Cavallazzi, Rodrigo Aliberti, Stefano Jonsson, Colleen Arnold, Forest Bordon, Jose Fernandez-Botran, Rafael Kelley, Robert Morlacchi, Letizia Peyrani, Paula Ramirez, Julio Rane, Madhavi Rodriguez-Hernandez, Lisandra Uppatla, Srinivas Uriarte, Silvia Wiemken, Timothy
source	PMC
abstract	The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (PSI ≥ 91 points). Blood and sputum samples were collected upon admission. Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of pro- and anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. Blood neutrophil functional responses were elevated in CAP patients compared to healthy controls. However, neutrophils from severe CAP patients showed reduced respiratory burst activity compared to the non-severe group. Results indicate that patients with severe CAP fail to mount a robust local pro-inflammatory response but exhibit instead a more substantial systemic inflammatory response, suggesting that a key driver of CAP severity may be the ability of the patient to generate an optimal local inflammatory response. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10753-014-9840-2) contains supplementary material, which is available to authorized users.
has issue date	2014-02-21(xsd:dateTime)
bibo:doi	10.1007/s10753-014-9840-2
bibo:pmid	24557760
has license	no-cc
sha1sum (hex)	3b62d9e58b367253244fea6ac7ce9bc5c6e5ce4b
schema:url	https://doi.org/10.1007/s10753-014-9840-2
resource representing a document's title	Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia
has PubMed Central identifier	PMC7087758
has PubMed identifier	24557760
schema:publication	Inflammation
resource representing a document's body	covid:3b62d9e58b367253244fea6ac7ce9bc5c6e5ce4b#body_text
is schema:about of	named entity 'SEVERE' named entity 'patients' named entity 'concentrations' named entity 'patients' named entity 'ABILITY' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'NEUTROPHILS' named entity 'REDUCED' named entity 'ADMISSION' named entity 'LOCAL' named entity 'ELEVATED' named entity 'PRO-INFLAMMATORY RESPONSE' named entity 'DRIVER' named entity 'PLASMA' named entity 'FAIL' named entity 'NON-' named entity 'PNEUMONIA SEVERITY INDEX' named entity 'OBJECTIVE' named entity 'SEVERE' named entity 'TO COMPARE' named entity 'ANTI-INFLAMMATORY' named entity 'SAMPLES' named entity 'PRO-' named entity 'FUNCTIONAL' named entity 'ACCORDING' named entity 'PATIENTS' named entity 'CYTOKINES' named entity 'HOSPITALIZED PATIENTS' named entity 'EXHIBIT' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'OPTIMAL' named entity 'COLLECTED' named entity 'SEVERITY' named entity 'RESPIRATORY BURST' named entity 'ROBUST' named entity 'INFLAMMATORY RESPONSES' named entity 'LOWER' named entity 'NON-' named entity 'CONTRASTING' named entity 'CONTRAST' named entity 'RESULTS' named entity 'CONCENTRATIONS' named entity 'ACTIVITY' named entity 'BLOOD' named entity 'HEALTHY' named entity 'COMPARED' named entity 'CYTOKINE ' named entity 'PATIENT' named entity 'NEUTROPHIL' named entity 'SYSTEMIC' named entity 'CAP' named entity 'INFLAMMATORY RESPONSE' named entity 'STUDY' named entity 'GROUP' named entity 'GENERATE' named entity 'MAY BE' named entity 'SPUTUM' named entity 'POINTS' named entity 'RESPONSES' named entity 'INFLAMMATORY' named entity 'LEVELS' named entity 'GROUPED' named entity 'MOUNT' named entity 'BUT' named entity 'HIGHER' named entity 'KEY'

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