About: Nasopharyngeal Microbiota in Infants With Acute Otitis Media

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nasopharyngeal Microbiota in Infants With Acute Otitis Media
Creator	Qi, Weihong Hilty, Markus Aebi, Suzanne Agyeman, Philipp Brugger, Silvio Frei, Laurence Frey, Pascal Mü Hlemann, Kathrin
Source	Medline; PMC
abstract	Background. Interspecies interactions of the nasopharyngeal microbiota are likely to be involved in the pathogenesis of acute otitis media (AOM). Capturing the breadth of microbial interactions requires a detailed description of the microbiota during health and AOM. Methods. The nasopharyngeal microbiota of 163 infants with (n = 153) or without (n = 10) AOM was characterized using nasopharyngeal swabs and multiplexed pyrosequencing of 16S rRNA. Nasopharyngeal swab specimens were collected during 4 winter seasons from 2004 through 2010 for infants with AOM and during 2010 for controls. Results. Fifty-eight bacterial families were identified, of which Moraxellaceae, Streptococcaceae, and Pasteurellaceae were the most frequent. Commensal families were less prevalent in infants with AOM than in controls. In infants with AOM, prior exposure to antimicrobials and administration of the heptavalent conjugated pneumococcal polysaccharide vaccine (PCV7) were also associated with reduced prevalence of distinct commensal families (Streptococcaceae and Corynebacteriaceae). In addition, antimicrobial exposure increased the prevalence of Enterobacteriaceae and the abundance of Pasteurellaceae. Other factors, such as age, sex, day care, and a history of recurrent AOM, did not influence the microbiota. Conclusions. Infants’ nasopharyngeal microbiota undergoes significant changes during AOM and after exposure to antimicrobials and PCV7, which is mainly attributable to reduced prevalence of commensal bacterial families.
has issue date	2012-04-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jis024
bibo:pmid	22351941
has license	no-cc
sha1sum (hex)	3bf778a7e84f062dd8e7a5d37a023a54968236cd
schema:url	https://doi.org/10.1093/infdis/jis024
resource representing a document's title	Nasopharyngeal Microbiota in Infants With Acute Otitis Media
has PubMed Central identifier	PMC7107284
has PubMed identifier	22351941
schema:publication	J Infect Dis
resource representing a document's body	covid:3bf778a7e84f062dd8e7a5d37a023a54968236cd#body_text
is schema:about of	named entity 'interactions' named entity 'Otitis' named entity 'With' named entity 'MICROBIAL INTERACTIONS' named entity 'DESCRIPTION' named entity 'ACUTE OTITIS MEDIA' named entity 'NASOPHARYNGEAL' named entity 'MICROBIOTA' named entity 'ACUTE OTITIS MEDIA' named entity 'INFANTS' named entity 'AOM' named entity 'BREADTH' named entity 'PATHOGENESIS' named entity 'DETAILED' named entity 'INTERACTIONS' named entity 'INVOLVED' named entity 'LIKELY' named entity 'NASOPHARYNGEAL' named entity 'BACKGROUND' named entity 'MICROBIOTA' named entity 'HEALTH' covid:arg/3bf778a7e84f062dd8e7a5d37a023a54968236cd named entity 'microbiota' named entity 'health' named entity 'microbiota' named entity 'AOM' named entity 'microbial' named entity 'nasopharyngeal' named entity 'acute otitis media' named entity 'Nasopharyngeal' named entity 'commensal' named entity 'AOM' named entity 'AOM' named entity 'PCV7' named entity 'AOM' named entity 'selection bias' named entity 'AOM' named entity 'vaccination' named entity 'day care' named entity 'clinical characteristics' named entity 'pathogens' named entity 'institutional review boards' named entity 'microbiota' named entity 'AOM' named entity 'virulence factors' named entity 'OTUs' named entity 'commensals' named entity 'microbiota' named entity 'amplicon sequencing' named entity 'Factorial' named entity 'antibiotic' named entity 'AOM' named entity 'PCV7' named entity 'statistically significant' named entity 'microbiota' named entity 'AOM' named entity 'AOM' named entity 'nasopharyngeal swab' named entity 'microbiota' named entity 'variable regions' named entity 'antibiotic' named entity 'Streptococcaceae' named entity 'statistically significant' named entity 'Diversity indices' named entity 'antimicrobial' named entity 'Moraxellaceae' named entity 'vegan' named entity 'Mothur' named entity 'AOM' named entity 'AOM' named entity 'AOM' named entity 'PCV7' named entity 'streptococci' named entity 'RNA viruses'

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