About: Spiky nanostructures for virus inhibition and infection prevention

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spiky nanostructures for virus inhibition and infection prevention
Creator	Bao, Jinku Cheng, Chong Luo, Hongrong Ma, Lang Nie, Chuanxiong
Source	Elsevier; PMC
abstract	Abstract The outbreak of a novel highly infectious virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has aroused people’s concern about public health. The lack of ready-to-use vaccines and therapeutics makes the fight with these pathogens extremely difficult. To this point, rationally designed virus entry inhibitors that block the viral interaction with its receptor can be novel strategies to prevent virus infection. For ideal inhibition of the virus, the virus-inhibitor interaction has to outperform the virus-host interaction. In our view, the morphology of the inhibitor should be carefully designed to benefit virus-inhibitor binding, especially that the surfaces of viruses are mostly rough due to the existence of surface proteins for receptor-binding. In this perspective article, we would like to discuss the recent progress of designing inhibitors with spiky topography to maximize the interactions between viruses and inhibitors. We also would like to share our idea for the future study of inhibitors to prevent virus infection.
has issue date	2020-07-16(xsd:dateTime)
bibo:doi	10.1016/j.smaim.2020.07.004
has license	els-covid
sha1sum (hex)	3c0d36a7ae4ecbf30785d7af26f9081d514428d7
schema:url	https://doi.org/10.1016/j.smaim.2020.07.004
resource representing a document's title	Spiky nanostructures for virus inhibition and infection prevention
has PubMed Central identifier	PMC7363616
resource representing a document's body	covid:3c0d36a7ae4ecbf30785d7af26f9081d514428d7#body_text
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