About: Risk Factors for SARS Transmission from Patients Requiring Intubation: A Multicentre Investigation in Toronto, Canada

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About: Risk Factors for SARS Transmission from Patients Requiring Intubation: A Multicentre Investigation in Toronto, Canada Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk Factors for SARS Transmission from Patients Requiring Intubation: A Multicentre Investigation in Toronto, Canada
Creator	Gravel, Denise Vearncombe, Mary Green, Karen Loeb, Mark Henry, Bonnie Ofner, Marianna Simor, Andrew Lapinsky, Stephen Bontovics, Erika Chapman, Martin Paton, Shirley Raboud, Janet Reynolds, Donna Scales, Damon Shen, Sandy Shigayeva, Altynay Stewart, Thomas Zoutman, Dick Mcdonald, L Mcgeer, Allison
Source	Medline; PMC
abstract	BACKGROUND: In the 2003 Toronto SARS outbreak, SARS-CoV was transmitted in hospitals despite adherence to infection control procedures. Considerable controversy resulted regarding which procedures and behaviours were associated with the greatest risk of SARS-CoV transmission. METHODS: A retrospective cohort study was conducted to identify risk factors for transmission of SARS-CoV during intubation from laboratory confirmed SARS patients to HCWs involved in their care. All SARS patients requiring intubation during the Toronto outbreak were identified. All HCWs who provided care to intubated SARS patients during treatment or transportation and who entered a patient room or had direct patient contact from 24 hours before to 4 hours after intubation were eligible for this study. Data was collected on patients by chart review and on HCWs by interviewer-administered questionnaire. Generalized estimating equation (GEE) logistic regression models and classification and regression trees (CART) were used to identify risk factors for SARS transmission. RESULTS: 45 laboratory-confirmed intubated SARS patients were identified. Of the 697 HCWs involved in their care, 624 (90%) participated in the study. SARS-CoV was transmitted to 26 HCWs from 7 patients; 21 HCWs were infected by 3 patients. In multivariate GEE logistic regression models, presence in the room during fiberoptic intubation (OR = 2.79, p = .004) or ECG (OR = 3.52, p = .002), unprotected eye contact with secretions (OR = 7.34, p = .001), patient APACHE II score ≥20 (OR = 17.05, p = .009) and patient Pa0(2)/Fi0(2) ratio ≤59 (OR = 8.65, p = .001) were associated with increased risk of transmission of SARS-CoV. In CART analyses, the four covariates which explained the greatest amount of variation in SARS-CoV transmission were covariates representing individual patients. CONCLUSION: Close contact with the airway of severely ill patients and failure of infection control practices to prevent exposure to respiratory secretions were associated with transmission of SARS-CoV. Rates of transmission of SARS-CoV varied widely among patients.
has issue date	2010-05-19(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0010717
bibo:pmid	20502660
has license	cc-by
sha1sum (hex)	3c1893f7c0ec143b4f173980381354e5cfe6416f
schema:url	https://doi.org/10.1371/journal.pone.0010717
resource representing a document's title	Risk Factors for SARS Transmission from Patients Requiring Intubation: A Multicentre Investigation in Toronto, Canada
has PubMed Central identifier	PMC2873403
has PubMed identifier	20502660
schema:publication	PLoS One
resource representing a document's body	covid:3c1893f7c0ec143b4f173980381354e5cfe6416f#body_text
is schema:about of	named entity 'CANADA' named entity 'SARS' named entity 'TRANSMISSION' named entity 'SARS-COV' named entity 'BACKGROUND' named entity 'BEHAVIOURS' named entity 'TRANSMITTED' named entity 'HOSPITALS' named entity 'CONSIDERABLE' named entity 'CONTROVERSY' named entity 'PATIENTS' named entity 'INVESTIGATION' named entity 'TORONTO' named entity 'TORONTO' named entity 'RISK FACTORS' named entity 'RISK OF' named entity 'ASSOCIATED WITH' named entity 'ADHERENCE' named entity 'INFECTION CONTROL PROCEDURES' named entity 'SARS' named entity 'INTUBATION' named entity 'OUTBREAK' named entity 'GREATEST' named entity 'PROCEDURES' covid:arg/3c1893f7c0ec143b4f173980381354e5cfe6416f named entity 'SARS-CoV' named entity 'infection control' named entity 'SARS-CoV' named entity 'Toronto' named entity 'Toronto' named entity 'Canada' named entity 'fever' named entity 'GEE' named entity 'SARS' named entity 'vector-borne diseases' named entity 'intubation' named entity 'PPE' named entity 'symptom' named entity 'influenza' named entity 'SARS' named entity 'HCW' named entity 'serology' named entity 'catheters' named entity 'pneumonia' named entity 'intubation' named entity 'statistical significance' named entity 'RT-PCR' named entity 'intubation' named entity 'SARS' named entity 'higher risk' named entity 'fiber optic' named entity 'healthcare workers' named entity 'modes of transmission' named entity 'serum' named entity 'SARS' named entity 'SARS-CoV' named entity 'infection' named entity 'SARS-CoV' named entity 'vomiting' named entity 'Health Care' named entity 'airway management' named entity 'data collection'

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