About: Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

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About: Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells
Creator	Jones, Elizabeth Bartoli, Fiona Beech, David Caolo, Vincenza Debant, Marjolaine »more»
topic	covid:3c1bbb9a97095177d625888b1b0871f00f92ec4d#this
source	PMC
abstract	Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured microvascular endothelial cells, Piezo1 channel activation by either shear stress or a chemical agonist Yoda1 activated a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), a Ca(2+)-regulated transmembrane sheddase that mediates S2 Notch1 cleavage. Consistent with this observation, we found Piezo1-dependent increase in the abundance of Notch1 intracellular domain (NICD) that depended on ADAM10 and the downstream S3 cleavage enzyme, γ-secretase. Conditional endothelial-specific disruption of Piezo1 in adult mice suppressed the expression of multiple Notch1 target genes in hepatic vasculature, suggesting constitutive functional importance in vivo. The data suggest that Piezo1 is a mechanism conferring force sensitivity on ADAM10 and Notch1 with downstream consequences for sustained activation of Notch1 target genes and potentially other processes.
has issue date	2020-06-02(xsd:dateTime)
bibo:doi	10.7554/elife.50684
bibo:pmid	32484440
has license	cc-by
sha1sum (hex)	3c1bbb9a97095177d625888b1b0871f00f92ec4d
schema:url	https://doi.org/10.7554/elife.50684
resource representing a document's title	Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells
has PubMed Central identifier	PMC7295575
has PubMed identifier	32484440
resource representing a document's body	covid:3c1bbb9a97095177d625888b1b0871f00f92ec4d#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/3c1bbb9a97095177d625888b1b0871f00f92ec4d
is schema:about of	named entity 'chemical' named entity 'Mechanical' named entity 'endothelial cells' named entity 'intracellular' named entity 'genes' »more»

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