About: Immune-mediated neurological syndromes in SARS-CoV-2-infected patients

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Immune-mediated neurological syndromes in SARS-CoV-2-infected patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune-mediated neurological syndromes in SARS-CoV-2-infected patients
Creator	Anantharajah, Ahalieyah Belkhir, Leila Bronchain, Maroussia Capes, Antoine Cyr, Jean De Greef, Julien Fillée, Catherine Guilmot, Antoine Halil Yildiz, · Hanseeuw, · Hantson, Philippe Ivanoiu, Adrian Jacquerye, Philippe London, Frederic Maggi, Pietro Maldonado, Sofia Pothen, · Raymackers, Jean-Marc Sankari, El Sellimi, Amina Slootjes, Maldonado Sofia, · Souraya, · Thierry Duprez, · Van Pesch, Vincent
topic	covid:3c57213886600b91fe4265b91726105fc8e01809#this
Source	Medline; PMC
abstract	BACKGROUND: Evidence of immune-mediated neurological syndromes associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is limited. We therefore investigated clinical, serological and CSF features of coronavirus disease 2019 (COVID-19) patients with neurological manifestations. METHODS: Consecutive COVID-19 patients with neurological manifestations other than isolated anosmia and/or non-severe headache, and with no previous neurological or psychiatric disorders were prospectively included. Neurological examination was performed in all patients and lumbar puncture with CSF examination was performed when not contraindicated. Serum anti-gangliosides antibodies were tested when clinically indicated. RESULTS: Of the 349 COVID-19 admitted to our center between March 23rd and April 24th 2020, 15 patients (4.3%) had neurological manifestations and fulfilled the study inclusion/exclusion criteria. CSF examination was available in 13 patients and showed lymphocytic pleocytosis in 2 patients: 1 with anti-contactin-associated protein 2 (anti-Caspr2) antibody encephalitis and 1 with meningo-polyradiculitis. Increased serum titer of anti-GD1b antibodies was found in three patients and was associated with variable clinical presentations, including cranial neuropathy with meningo-polyradiculitis, brainstem encephalitis and delirium. CSF PCR for SARS-CoV-2 was negative in all patients. CONCLUSIONS: In SARS-Cov-2 infected patients with neurological manifestations, CSF pleocytosis is associated with para- or post-infectious encephalitis and polyradiculitis. Anti-GD1b and anti-Caspr2 autoantibodies can be identified in certain cases, raising the question of SARS-CoV-2-induced secondary autoimmunity.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1007/s00415-020-10108-x
bibo:pmid	32734353
has license	cc-by
sha1sum (hex)	3c57213886600b91fe4265b91726105fc8e01809
schema:url	https://doi.org/10.1007/s00415-020-10108-x
resource representing a document's title	Immune-mediated neurological syndromes in SARS-CoV-2-infected patients
has PubMed Central identifier	PMC7391231
has PubMed identifier	32734353
schema:publication	J Neurol
resource representing a document's body	covid:3c57213886600b91fe4265b91726105fc8e01809#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/3c57213886600b91fe4265b91726105fc8e01809
is schema:about of	named entity 'study' named entity 'presentations' named entity 'performed' named entity 'COVID-19' named entity 'serum' named entity 'March' named entity 'patients' named entity 'CSF' named entity 'EXAMINATION' named entity 'ENCEPHALITIS' named entity 'INFECTION' named entity 'EVIDENCE OF' named entity 'SARS-CoV-2' named entity 'serological' named entity 'inclusion' named entity 'coronavirus disease 2019' named entity 'severe acute respiratory syndrome coronavirus' named entity 'neurological syndromes' named entity 'patients' named entity 'manifestations' named entity 'contraindicated' named entity 'autoimmunity' named entity 'CSF' named entity 'SARS-Cov-2' named entity 'neurological' named entity 'lymphocytic pleocytosis' named entity 'severe headache' named entity 'SARS-CoV-2' named entity 'serum' named entity 'CSF pleocytosis' named entity 'Serum' named entity 'COVID-19' named entity 'autoantibodies' named entity 'SARS-CoV-2' named entity 'respiratory symptoms' named entity 'COVID' named entity 'CASPR2' named entity 'delirium' named entity 'cerebrovascular disease' named entity 'cough' named entity 'neurological syndromes' named entity 'neoplasm' named entity 'nasopharyngeal swabs' named entity 'Bickerstaff brainstem encephalitis' named entity 'anxiety' named entity 'ophthalmoplegia' named entity 'human parechovirus' named entity 'anorexia' named entity 'Serum' named entity 'SARS-CoV-2' named entity 'autoantibodies' named entity 'IgG antibodies' named entity 'anti-NMDAR encephalitis' named entity 'neuropsychiatric' named entity 'palatal tremor'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software