About: Prevalence of Group A Streptococcus in Primary Care Patients and the Utility of C-Reactive Protein and Clinical Scores for Its Identification in Thailand

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About: Prevalence of Group A Streptococcus in Primary Care Patients and the Utility of C-Reactive Protein and Clinical Scores for Its Identification in Thailand Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prevalence of Group A Streptococcus in Primary Care Patients and the Utility of C-Reactive Protein and Clinical Scores for Its Identification in Thailand
Creator	Althaus, Thomas Thaipadungpanit, Janjira Butler, Christopher Day, Nicolas Greer, Rachel Intralawan, Daranee Ling, Clare Lubell, Yoel Nedsuwan, Supalert Wangrangsimakul, Tri
topic	covid:3cc1733c40062f59a5d1e9c7c9fd318c8041c0a2#this
source	PMC
abstract	Pharyngitis is usually caused by a viral infection for which antibiotics are often unnecessarily prescribed, adding to the burden of antimicrobial resistance. Identifying who needs antibiotics is challenging; microbiological confirmation and clinical scores are used but have limitations. In a cross-sectional study nested within a randomized controlled trial, we estimated the prevalence and antibiotic susceptibility profiles of group A Streptococcus (GAS) in patients presenting to primary care with a sore throat and fever in northern Thailand. We then evaluated the use of C-reactive protein (CRP) and clinical scores (Centor and FeverPAIN) to identify the presence of GAS. One hundred sixty-nine patients were enrolled, of whom 35 (20.7%) had β-hemolytic Streptococci (BHS) isolated from throat swab culture, and 11 (6.5%) had GAS. All GAS isolates were sensitive to penicillin G. The median CRP of those without BHS isolation was 10 mg/L (interquartile range [IQR] ≤ 8–18), compared with 18 mg/L (IQR 9–71, P = 0.0302) for those with GAS and 14 mg/L (IQR ≤ 8–38, P = 0.0516) for those with any BHS isolated. However, there were no significant relationships between CRP > 8 mg/L (P = 0.112), Centor ≥ 3 (P = 0.212), and FeverPAIN ≥ 4 (P = 1.000), and the diagnosis of GAS compared with no BHS isolation. Identifying who requires antibiotics for pharyngitis remains challenging and necessitates further larger studies. C-reactive protein testing alone, although imperfect, can reduce prescribing compared with routine care. Targeted CRP testing through clinical scoring may be the most cost-effective approach to ruling out GAS infection.
has issue date	2019-12-30(xsd:dateTime)
bibo:doi	10.4269/ajtmh.19-0502
bibo:pmid	31889507
has license	cc-by
sha1sum (hex)	3cc1733c40062f59a5d1e9c7c9fd318c8041c0a2
schema:url	https://doi.org/10.4269/ajtmh.19-0502
resource representing a document's title	Prevalence of Group A Streptococcus in Primary Care Patients and the Utility of C-Reactive Protein and Clinical Scores for Its Identification in Thailand
has PubMed Central identifier	PMC7008346
has PubMed identifier	31889507
schema:publication	Am J Trop Med Hyg
resource representing a document's body	covid:3cc1733c40062f59a5d1e9c7c9fd318c8041c0a2#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/3cc1733c40062f59a5d1e9c7c9fd318c8041c0a2
is schema:about of	named entity 'primary care' named entity 'evaluated' named entity 'CRP' named entity 'adding' named entity 'Patients' covid:arg/3cc1733c40062f59a5d1e9c7c9fd318c8041c0a2 named entity 'IDENTIFICATION' named entity 'SCORES' named entity 'RELATIONSHIPS' named entity 'GROUP A STREPTOCOCCUS' named entity 'SCORING' named entity 'RANDOMIZED CONTROLLED TRIAL' named entity 'MG%' named entity 'CROSS-SECTIONAL STUDY' named entity 'CARE' named entity 'FEVER' named entity 'APPROACH' named entity 'USE OF' named entity 'ISOLATES' named entity 'CRP' named entity 'EVALUATED' named entity 'SIXTY-NINE' named entity 'SORE THROAT' named entity 'LARGER' named entity 'NEEDS' named entity 'COST' named entity 'ISOLATED' named entity 'ANTIBIOTIC SUSCEPTIBILITY' named entity 'ESTIMATED' named entity 'C-REACTIVE PROTEIN' named entity 'RANGE' named entity 'ANTIBIOTICS' named entity 'NORTHERN' named entity 'EFFECTIVE' named entity 'PREVALENCE' named entity 'PHARYNGITIS' named entity 'ADDING' named entity 'PENICILLIN G' named entity 'UTILITY' named entity 'GROUP A STREPTOCOCCUS' named entity '212' named entity 'SIGNIFICANT' named entity 'TESTING' named entity 'COMPARED' named entity 'PRESENTING' named entity 'LIMITATIONS' named entity 'HEMOLYTIC' named entity 'ROUTINE' named entity 'C-REACTIVE PROTEIN' named entity 'CLINICAL' named entity 'GAS' named entity '28P' named entity 'BURDEN' named entity 'ENROLLED' named entity 'THROAT SWAB' named entity 'THAILAND' named entity 'ITS' named entity 'PATIENTS' named entity 'ISOLATION' named entity 'STREPTOCOCCUS ' named entity 'PROTEIN ' named entity 'PRIMARY CARE' named entity 'CONFIRMATION' named entity 'REDUCE' named entity 'BHS' named entity 'ANTIMICROBIAL RESISTANCE' named entity 'USUALLY' named entity 'RULING' named entity 'ONE HUNDRED' named entity 'STUDIES'

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