About: Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs

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About: Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs
Creator	Diot, Cédric Fournier, Guillaume Komarova, Anastasia Magnus, Julie Munier, Sandie Naffakh, Nadia Van Der Werf, Sylvie Santos, Mélanie
Source	PMC
abstract	Enhancing the knowledge of host factors that are required for efficient influenza A virus (IAV) replication is essential to address questions related to pathogenicity and to identify targets for antiviral drug development. Here we focused on the interplay between IAV and DExD-box RNA helicases (DDX), which play a key role in cellular RNA metabolism by remodeling RNA-RNA or RNA-protein complexes. We performed a targeted RNAi screen on 35 human DDX proteins to identify those involved in IAV life cycle. DDX19 was a major hit. In DDX19-depleted cells the accumulation of viral RNAs and proteins was delayed, and the production of infectious IAV particles was strongly reduced. We show that DDX19 associates with intronless, unspliced and spliced IAV mRNAs and promotes their nuclear export. In addition, we demonstrate an RNA-independent association between DDX19 and the viral polymerase, that is modulated by the ATPase activity of DDX19. Our results provide a model in which DDX19 is recruited to viral mRNAs in the nucleus of infected cells to enhance their nuclear export. Information gained from this virus-host interaction improves the understanding of both the IAV replication cycle and the cellular function of DDX19.
has issue date	2016-09-22(xsd:dateTime)
bibo:doi	10.1038/srep33763
bibo:pmid	27653209
has license	cc-by
sha1sum (hex)	3ccac237e5fa57c9d28f59f0b9b8e58188edd29b
schema:url	https://doi.org/10.1038/srep33763
resource representing a document's title	Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs
has PubMed Central identifier	PMC5037575
has PubMed identifier	27653209
schema:publication	Sci Rep
resource representing a document's body	covid:3ccac237e5fa57c9d28f59f0b9b8e58188edd29b#body_text
is schema:about of	named entity 'NUCLEAR EXPORT' named entity 'interplay' named entity 'DDX' named entity 'human' named entity 'viral' named entity 'remodeling' named entity 'mRNAs' named entity 'function' named entity 'identify' named entity 'focused' named entity 'pathogenicity' named entity 'cellular' named entity 'RNA HELICASE' named entity 'ACCUMULATION' named entity 'DELAYED' named entity 'BOX' named entity 'PROTEIN COMPLEXES' named entity 'HIT' named entity 'DDX19' named entity 'DDX' named entity 'ANTIVIRAL DRUG' named entity 'REMODELING' named entity 'ROLE' named entity 'MODEL' named entity 'DRUG DEVELOPMENT' named entity 'RNA HELICASES' named entity 'VIRAL POLYMERASE' named entity 'RESULTS' named entity 'INFECTIOUS' named entity 'NUCLEAR EXPORT' named entity 'PRODUCTION' named entity 'KEY' named entity 'UNDERSTANDING' named entity 'ESSENTIAL' named entity 'ADDITION' named entity 'FOCUSED' named entity 'ASSOCIATION' named entity 'NUCLEUS' named entity 'PATHOGENICITY' named entity 'PROMOTE' named entity 'MRNAS' named entity 'VIRAL' named entity 'RNA METABOLISM' named entity 'INFORMATION' named entity 'CELLULAR' named entity 'PROVIDE' named entity 'PARTICLES' named entity 'DEPLETED' named entity 'ENHANCE' named entity 'HERE' covid:arg/3ccac237e5fa57c9d28f59f0b9b8e58188edd29b named entity 'POLYMERASE' named entity 'INFLUENZA A VIRUS' named entity 'VIRAL' named entity 'DDX19' named entity 'INVOLVED' named entity 'ADDRESS' named entity 'MODULATED' named entity 'SPLICED' named entity 'CELLULAR FUNCTION' named entity 'MRNAS' named entity 'PLAY' named entity 'REDUCED' named entity 'LIFE CYCLE' named entity 'VIRUS-HOST INTERACTION' named entity 'GAINED' named entity 'RNA' named entity 'OUR' named entity 'HUMAN' named entity 'IMPROVES' named entity 'PERFORMED' named entity 'REPLICATION CYCLE' named entity 'WAS A' named entity 'INFECTED'

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