About: Proven Epstein–Barr encephalitis with negative EBV‐DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia

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About: Proven Epstein–Barr encephalitis with negative EBV‐DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proven Epstein–Barr encephalitis with negative EBV‐DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia
Creator	Papoff, Paola Antonelli, Manila Badiali, Manuela Barberi, Walter Caresta, Elena Ceglie, Teresa Gentile, Giuseppe Giangaspero, Felice Gianno, Francesca Iori, Anna Melone, Antonio Moleti, Maria Perrone, Salvatore Testi, Anna Torelli, Giovanni Fo, Robin
Source	Medline; PMC
abstract	We report a case of EBV encephalitis in a seven‐yr‐old child with Ph+ ALL. Two months after an allogeneic HSCT from his HLA mismatched mother, the patient showed an altered sensorium, generalized seizures, and a left hemiparesis. Brain MRI demonstrated multiple lesions highly suggestive for viral encephalitis. Blood and CSF PCR analyses were negative for the most common viruses involved in immunocompromised patients including EBV. A cerebral biopsy was performed, which showed intense gliosis and perivascular lymphocytic cuffing. PCR analysis performed on brain tissue was positive only for the EBV genome, while extensive investigations for other viral infections were negative. The patient's neurological symptoms rapidly worsened and he died two months later. This case report suggests that in patients presenting neurological and radiological signs of encephalitis after an HSCT, an EBV involvement should be considered, even in the absence of CSF and blood PCR virus detection.
has issue date	2014-11-12(xsd:dateTime)
bibo:doi	10.1111/petr.12386
bibo:pmid	25388950
has license	no-cc
sha1sum (hex)	3d35465abd5eaf8207dc57efd5e3a6306f4405fe
schema:url	https://doi.org/10.1111/petr.12386
resource representing a document's title	Proven Epstein–Barr encephalitis with negative EBV‐DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia
has PubMed Central identifier	PMC7167730
has PubMed identifier	25388950
schema:publication	Pediatr Transplant
resource representing a document's body	covid:3d35465abd5eaf8207dc57efd5e3a6306f4405fe#body_text
is schema:about of	named entity 'case' named entity 'case report' named entity 'EBV' named entity 'MRI' named entity 'CEREBRAL BIOPSY' named entity 'LATER' named entity 'BLOOD' named entity 'CHILD' named entity 'ENCEPHALITIS' named entity 'CUFFING' named entity 'INVOLVEMENT' named entity 'REPORT' named entity 'PRESENTING' named entity 'EBV' named entity 'PCR' named entity 'involved' named entity 'encephalitis' named entity 'encephalitis' named entity 'allogeneic' named entity 'transplantation' named entity 'genome' named entity 'hemiparesis' named entity 'gliosis' named entity 'neurological symptoms' named entity 'case report' named entity 'CSF' named entity 'HSCT' named entity 'PCR analysis' named entity 'biopsy' named entity 'CSF' named entity 'HSCT' named entity 'PCR' named entity 'viruses' named entity 'allogeneic hematopoietic stem cell transplantation' named entity 'suggestive' named entity 'performed' named entity 'life-threatening disease' named entity 'hemiplegia' named entity 'etiology' named entity 'peripheral blood' named entity 'human coronavirus' named entity 'EBV' named entity 'EBV' named entity 'thiotepa' named entity 'EBV' named entity 'inflammatory cells' named entity 'enteroviruses' named entity 'adverse events' named entity 'foscarnet' named entity 'viral encephalitis' named entity 'aciclovir' named entity 'insular region' named entity 'chimerism' named entity 'thalamus' named entity 'IgG' named entity 'T-cell' named entity 'VZV' named entity 'VZV' named entity 'brain stem' named entity 'antiviral treatment' named entity 'T-cell' named entity 'normal range' named entity 'morbidity' named entity 'HSV-2' named entity 'glucose level' named entity 'methotrexate'

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