About: Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis
Creator	Wang, Lin Zhang, Lei Chen, Yan Chen, Xiao-Ping Wang, Chun-You Wu, He-Shui Zhang, Wan-Guang
Source	PMC
abstract	This study preliminarily investigated the mechanism by which chloroquine (CQ) relieves acute lung injury (ALI) complicated in acute hemorrhagic necrotizing pancreatitis (AHNP). Sixty male Wistar rats were randomized into sham-operated group (group A, n=10), AHNP group (group B, n=10), L-arginine-treated group (group C, n=10), L-N-nitro-L-arginine methyl ester (NAME)-treated group (group D, n=10), CQ-treated group (group E, n=10) and CQ+L-NAME-treated group (group F, n=10). TLR4 expression was measured by using real time-PCR and Western blotting respectively. The results showed that, in the group B, the expression of TLR4 and the levels of TNF-α and IL-6 in the lungs were significantly increased, and the nitric oxide (NO) concentration was reduced, as compared with those in the group A (P<0.05 or P<0.01). Lung injury was aggravated with the increased expression of TLR4. When the inhibitor and stimulator of TLR4, namely L-Arg and L-NAME, were added respectively, lung injury was correspondingly relieved or aggravated (P<0.05 or P<0.01). In the group E, TLR4 expression was substantially lower and NO concentration higher than those in the group B (P<0.05 or P<0.01). However, in the group F, NO concentration was markedly decreased, and the inhibitory effect of CQ on TLR4 expression and the relief of lung injury were weakened when compared with those in the group E (P<0.05 or P<0.01). It was concluded that TLR4 may play an important role in the pathogenesis and development of ALI complicated in AHNP. CQ could relieve ALI by decreasing the TLR4 expression and increasing the NO release.
has issue date	2013-06-17(xsd:dateTime)
bibo:doi	10.1007/s11596-013-1124-9
bibo:pmid	23771660
has license	no-cc
sha1sum (hex)	3d5467d7853fce9ef9948bc008aee18f526b656e
schema:url	https://doi.org/10.1007/s11596-013-1124-9
resource representing a document's title	Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis
has PubMed Central identifier	PMC7101714
has PubMed identifier	23771660
schema:publication	J Huazhong Univ Sci Technolog Med Sci
resource representing a document's body	covid:3d5467d7853fce9ef9948bc008aee18f526b656e#body_text
is schema:about of	named entity 'necrotizing' named entity 'inhibitory' named entity 'mechanism' named entity 'higher' named entity 'stimulator' named entity 'PATHOGENESIS' named entity 'GROUP E' named entity 'ROLE' named entity 'RELEASE' named entity 'HIGHER' named entity 'INHIBITORY EFFECT' named entity 'MARKEDLY' named entity 'THE LUNGS' named entity 'INCREASED' named entity 'lung injury' named entity 'group' named entity 'study' named entity 'compared' named entity 'group' named entity 'chloroquine' named entity 'Lung' named entity 'Western blotting' named entity 'group E' named entity 'Chloroquine' named entity 'nitric oxide' named entity 'pathogenesis' named entity 'ALI' named entity 'P<0.05' named entity 'nitric oxide' named entity 'PCR' named entity 'lung injury' named entity 'L-arginine' named entity 'P<0.05' named entity 'Chloroquine' named entity 'cytokines' named entity 'receptor' named entity 'nitric oxide' named entity 'lungs' named entity 'nitric oxide' named entity 'histological' named entity 'Mice' named entity 'anti-inflammatory' named entity 'nitric oxide' named entity 'TNF-α' named entity 'electrophoresis' named entity 'IL-6' named entity 'Up-regulated' named entity 'peptides' named entity 'TLR4' named entity 'infection' named entity 'cDNA' named entity 'ALI' named entity 'lungs' named entity 'nitrocellulose' named entity 'formalin' named entity 'histological' named entity 'clinical study' named entity 'caerulein' named entity 'mRNA' named entity 'SIRS' named entity 'amylase' named entity 'spectrophotometrically' named entity 'anti-sense' named entity 'pathogen-associated molecular pattern' named entity 'malaria' named entity 'TLR4' named entity 'TLR4' named entity 'acute pancreatitis' named entity 'China' named entity 'fibronectins' named entity 'nitric oxide' named entity 'acute pancreatitis' named entity 'pro-inflammatory' named entity 'antibody' named entity 'LSD'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software