About: The interplay between endoplasmic reticulum stress and inflammation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The interplay between endoplasmic reticulum stress and inflammation
Creator	Lourie, Rohan Mcguckin, Michael Hasnain, Sumaira Chen, Alice C-H Das, Indrajit
topic	covid:3d92d3c0d18bd3418980c5fd858877ffd8df0ad8#this
source	Medline; PMC
abstract	Endoplasmic reticulum (ER) stress may be both a trigger and consequence of chronic inflammation. Chronic inflammation is often associated with diseases that arise because of primary misfolding mutations and ER stress. Similarly, ER stress and activation of the unfolded protein response (UPR) is a feature of many chronic inflammatory and autoimmune diseases. In this review, we describe how protein misfolding and the UPR trigger inflammation, how environmental ER stressors affect antigen presenting cells and immune effector cells, and present evidence that inflammatory factors exacerbate protein misfolding and ER stress. Examples from both animal models of disease and human diseases are used to illustrate the complex interactions between ER stress and inflammation, and opportunities for therapeutic targeting are discussed. Finally, recommendations are made for future research with respect to the interaction of ER stress and inflammation.
has issue date	2012-01-17(xsd:dateTime)
bibo:doi	10.1038/icb.2011.112
bibo:pmid	22249202
has license	no-cc
sha1sum (hex)	3d92d3c0d18bd3418980c5fd858877ffd8df0ad8
schema:url	https://doi.org/10.1038/icb.2011.112
resource representing a document's title	The interplay between endoplasmic reticulum stress and inflammation
has PubMed Central identifier	PMC7165805
has PubMed identifier	22249202
schema:publication	Immunol Cell Biol
resource representing a document's body	covid:3d92d3c0d18bd3418980c5fd858877ffd8df0ad8#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/3d92d3c0d18bd3418980c5fd858877ffd8df0ad8
is schema:about of	named entity 'immune' named entity 'animal models' named entity 'illustrate' named entity 'interactions' named entity 'endoplasmic reticulum' named entity 'ANIMAL MODELS OF DISEASE' named entity 'CONSEQUENCE OF' named entity 'ENVIRONMENTAL' named entity 'AFFECT' named entity 'FUTURE' named entity 'trigger' named entity 'therapeutic' named entity 'autoimmune diseases' named entity 'chronic inflammation' named entity 'The' named entity 'unfolded protein response' named entity 'protein misfolding' named entity 'ER stress' named entity 'Chronic inflammation' named entity 'antigen presenting cells' named entity 'chronic inflammatory' named entity 'endoplasmic reticulum stress' named entity 'nitric oxide' named entity 'endothelial cells' named entity 'mucin' named entity 'inflammation' named entity 'eIF2a' named entity 'susceptible individual' named entity 'Genome-wide studies' named entity 'serum amyloid P' named entity 'danger signals' named entity 'macrophages' named entity 'cytokine' named entity 'microbes' named entity 'AKT' named entity 'wild-type' named entity 'lysosomal' named entity 'viral infection' named entity 'small intestine' named entity 'environmental factors' named entity 'obesity' named entity 'protein misfolding' named entity 'NF-kB' named entity 'cytoplasmic domain' named entity 'essential element' named entity 'cytoplasmic' named entity 'IFNg' named entity 'granulocyte' named entity 'ER-associated degradation' named entity 'UPR' named entity 'AGR2' named entity 'autoimmune disease' named entity 'protein aggregates' named entity 'inflammation' named entity 'UPR' named entity 'polymorphism' named entity 'chemokines' named entity 'secretory function' named entity 'IBD' named entity 'apoptosis' named entity 'protein misfolding' named entity 'eIF2a' named entity 'mutation' named entity 'intracellular signalling' named entity 'misfolding' named entity 'neutrophil elastase' named entity 'intestinal stem cells' named entity 'diabetes' named entity 'inflammation' named entity 'pancreatic beta cells' named entity 'IBD' named entity 'inter-molecular' named entity 'phenotype' named entity 'proteostasis' named entity 'viral infection'

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