About: Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis

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About: Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis
Creator	Li, Chen Li, Jia-Qi Liu, Zhi-Hong Chen, Qi-Lin Dis, Kidney Guo, / Guo, Guo-Ji Guo, Guoji Lang, / Lang, Yue Liu, / Xiang, / Xiang, Zhi-Dan
Source	PMC
abstract	BACKGROUND: The new coronavirus (SARS-CoV-2), which has been responsible for the recent coronavirus disease 2019 (COVID-19) pandemic, uses the cell receptor angiotensin converting enzyme-2 (ACE2) for entry and the serine protease TMPRSS2 for spike (S) protein priming. Meanwhile, the presence of B0AT1 (SLC6A19) may prevent TMPRSS2 from accessing the cutting position on ACE2. Identifying the expression of these cell receptor-related genes of SARS-CoV-2 is critical for understanding the pathogenesis of SARS-CoV-2 in various tissues, especially in the kidney. METHODS: The single-cell transcription datasets of the human cell landscape (HCL) and other relevant single-cell transcription databases were used to analyze the expression of ACE2, TMPRSS2, and SLC6A19 in various organs and tissues, but mainly in the kidney. RESULTS: ACE2 was significantly expressed in the S1, S2, and S3 segments of proximal tubule (PT) cells. TMPRSS2 was widely expressed in several renal tubule populations extending from the PT cells to the collection system cell type, of which intercalated cells and the distal convoluted tubule cells showed more significant expression than PT cells. Unexpectedly, although expressed on various renal tubule populations, SLC6A19 was mainly enriched in PT cells, in line with ACE2 expression. Although alveolar-type (AT) 2 cells of the lung and intestinal epithelial cells expressed ACE2 as well as PT cells, AT 2 cells significantly expressed TMPRSS2 but not SLC6A19, while all 3 genes were significantly expressed in intestinal epithelial cells. CONCLUSIONS: ACE2 was widely expressed in specific cell subgroups of various human tissues, especially in intestinal epithelial cells, kidney PT cells, and also AT 2 cells of the lung. These 3 types of cells demonstrated significant differences in the distribution of the cell receptor-related genes of SARS-CoV-2, which may indicate the diversity of cell surface structures and differences in the affinity between SARS-CoV-2 and cells.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1159/000508162
has license	cc-by-nc-nd
sha1sum (hex)	3dc5c216c26090ed74e0c8f1ddf6eaf9bd3c5c2b
schema:url	https://doi.org/10.1159/000508162
resource representing a document's title	Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis
has PubMed Central identifier	PMC7316659
schema:publication	Kidney Dis (Basel)
resource representing a document's body	covid:3dc5c216c26090ed74e0c8f1ddf6eaf9bd3c5c2b#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'renal tubule' named entity 'cells' named entity 'cells' named entity 'datasets' named entity 'receptor' named entity 'intestinal epithelial cells' named entity 'expressed' named entity 'genes' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity 'converting' named entity 'presence' named entity 'Results' named entity 'SARS-CoV-2' named entity 'Transcriptome' named entity 'AFFINITY' named entity 'AT1' named entity 'RELEVANT' named entity 'SARS-CoV-2' named entity 'priming' named entity 'intestinal epithelial cells' named entity 'tissues' named entity 'expressed' named entity 'kidney' named entity 'HCL' named entity 'enterocytes' named entity 'co-expression' named entity 'SARS-CoV-2' named entity 'nucleus' named entity 'HCL' named entity 'carboxyl' named entity 'transcriptome' named entity 'rectum' named entity 'quality control' named entity 'ACE2' named entity 'gene analysis' named entity 'kidney' named entity 'kidney' named entity 'virus' named entity 'enterocyte' named entity 'enterocytes' named entity 'volcano plot' named entity 'SLC6A19' named entity 'epithelial cells' named entity 'ACE2' named entity 'SLC6A19' named entity 'kidney cells' named entity 'COVID-19' named entity 'liver' named entity 'ACE2' named entity 'podocytes' named entity 'gene' named entity 'Expression of genes' named entity 'down-regulated' named entity 'recombinant' named entity 'ACE2' named entity 'enterocytes' named entity 'Broad Institute' named entity 'sequencing technology' named entity 'SARS-CoV-2' named entity 'single cells' named entity 'proteases' named entity 'ACE2' named entity 'Wilcoxon rank sum test' named entity 'amine' named entity 'sequencing depth' named entity 'ACE2' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'ACE2'

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