About: Interferon, Mx, and viral countermeasures

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon, Mx, and viral countermeasures
Creator	Weber, Friedemann Haller, Otto Kochs, Georg
Source	Elsevier; Medline; PMC
abstract	The interferon system provides a powerful and universal intracellular defense mechanism against viruses. Knockout mice defective in IFN signaling quickly succumb to all kinds of viral infections. Likewise, humans with genetic defects in interferon signaling die of viral disease at an early age. Among the known interferon-induced antiviral mechanisms, the Mx pathway is one of the most powerful. Mx proteins belong to the dynamin superfamily of large GTPases and have direct antiviral activity. They inhibit a wide range of viruses by blocking an early stage of the viral replication cycle. Likewise, the protein kinase R (PKR), and the 2–5 OAS/RNaseL system represent major antiviral pathways and have been extensively studied. Viruses, in turn, have evolved multiple strategies to escape the IFN system. They try to go undetected, suppress IFN synthesis, bind and neutralize secreted IFN molecules, block IFN signaling, or inhibit the action of IFN-induced antiviral proteins. Here, we summarize recent findings about the astonishing interplay of viruses with the IFN response pathway.
has issue date	2007-08-01(xsd:dateTime)
bibo:doi	10.1016/j.cytogfr.2007.06.001
bibo:pmid	17683972
has license	no-cc
sha1sum (hex)	3de86b0356f38fb81a118d23c16f51dafc458e63
schema:url	https://doi.org/10.1016/j.cytogfr.2007.06.001
resource representing a document's title	Interferon, Mx, and viral countermeasures
has PubMed Central identifier	PMC7185553
has PubMed identifier	17683972
schema:publication	Cytokine Growth Factor Rev
resource representing a document's body	covid:3de86b0356f38fb81a118d23c16f51dafc458e63#body_text
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