About: Decreased NHE3 activity and trafficking in TGEV-infected IPEC-J2 cells via the SGLT1-mediated P38 MAPK/AKt2 pathway

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About: Decreased NHE3 activity and trafficking in TGEV-infected IPEC-J2 cells via the SGLT1-mediated P38 MAPK/AKt2 pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Decreased NHE3 activity and trafficking in TGEV-infected IPEC-J2 cells via the SGLT1-mediated P38 MAPK/AKt2 pathway
Creator	Yang, Yang Wang, Kai Huang, Shilei Ran, Ling Song, Zhenhui Xie, Luyi Yu, Qiuhan Yan, Tao Kan, Zifei Niu, Zheng Zhang, Yilin Song, Han
Source	Elsevier; Medline; PMC
abstract	Abstract Transmissible gastroenteritis virus (TGEV) primarily replicates in intestinal epithelial cells and causes severe damage to host cells, resulting in diarrhea. Surface NHE3 serves as the key regulatory site controlling electroneutral Na+ absorption. In this study, our results showed that the surface NHE3 content was significantly reduced following TGEV infection, whereas the total level of protein expression was not significantly changed, and NHE3 activity gradually decreased with prolonged infection time. We then inhibited SGLT1 expression by lentiviral interference and drug inhibition, respectively. Inhibition studies showed that the level of phosphorylation of the downstream key proteins, MAPKAPK-2 and EZRIN, in the SGLT1-mediated p38MAPK/AKt2 signaling pathway was significantly increased. The surface NHE3 expression was also significantly increased, and NHE3 activity was also significantly enhanced. These results demonstrate that a TGEV infection can inhibit NHE3 translocation and attenuates sodium-hydrogen exchange activity via the SGLT1-mediated p38MAPK/AKt2 signaling pathway, affecting cellular electrolyte absorption leading to diarrhea.
has issue date	2020-04-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2020.197901
bibo:pmid	32070687
has license	els-covid
sha1sum (hex)	3dfe29d041cefc6bf7640ae82e2512dba55d9a7d
schema:url	https://doi.org/10.1016/j.virusres.2020.197901
resource representing a document's title	Decreased NHE3 activity and trafficking in TGEV-infected IPEC-J2 cells via the SGLT1-mediated P38 MAPK/AKt2 pathway
has PubMed Central identifier	PMC7114662
has PubMed identifier	32070687
schema:publication	Virus Research
resource representing a document's body	covid:3dfe29d041cefc6bf7640ae82e2512dba55d9a7d#body_text
is schema:about of	named entity 'attenuates' named entity 'activity' named entity 'host' named entity 'diarrhea' named entity 'expression' named entity 'CONTROLLING' named entity 'SEVERE' named entity 'SGLT1' named entity 'MEDIATED' named entity 'SITE' named entity 'SIGNALING PATHWAY' named entity 'STUDIES' named entity 'ENHANCED' named entity 'KEY' named entity 'HOST CELLS' named entity 'DRUG' named entity 'PROTEIN EXPRESSION' named entity 'PHOSPHORYLATION' named entity 'INFECTION' named entity 'CAUSES' named entity 'REGULATORY' named entity 'FOLLOWING' named entity 'DOWNSTREAM' named entity 'SGLT1' named entity 'THESE' named entity 'TIME' named entity 'LEVEL' named entity 'ACTIVITY' named entity 'NHE3' named entity 'TRAFFICKING' named entity 'TGEV' named entity 'CELLS' named entity 'PATHWAY' named entity 'EXPRESSION' named entity 'SURFACE' named entity 'NHE3' named entity 'DIARRHEA' named entity 'P38 MAPK' named entity 'SODIUM' named entity 'P38MAPK' named entity 'PROTEINS' named entity 'DECREASED' named entity 'INFECTED' named entity 'EPITHELIAL CELLS' named entity 'HYDROGEN' named entity 'INCREASED' named entity 'DAMAGE' named entity 'ACTIVITY' named entity 'DECREASED' named entity 'MAPKAPK-2' named entity 'CELLULAR' named entity 'CONTENT' named entity 'INTESTINAL' named entity 'LEADING' named entity 'TRANSLOCATION' named entity 'REPLICATES' named entity 'ABSORPTION' named entity 'CHANGED' named entity 'AFFECTING' named entity 'RESULTING IN' named entity 'ELECTROLYTE' named entity 'INTERFERENCE' named entity 'INHIBITION' named entity 'TOTAL' named entity 'REDUCED' named entity 'OUR' named entity 'EXCHANGE' named entity 'PROLONGED' named entity 'RESULTS' named entity 'MEDIATED'

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