About: Fimbriae assisted bacterial surface display of heterologous peptides

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fimbriae assisted bacterial surface display of heterologous peptides
Creator	Klemm, Per Schembri, Mark
Source	PMC
abstract	The display of peptide segments on the surface of bacteria offers many new and exciting applications in biotechnology and medical research. Fimbria-assisted display of heterologous sequences is a paradigm for chimeric organelle display on bacteria. Fimbriae are particularly attractive candidates for epitope display for several reasons: (1) they are present in extremely high numbers at the cell surface, (2) they are strong immunogens, (3) they possess inherent adhesive properties, and (4) they can be easily purified. The majority of work dealing with fimbria-assisted peptide display has been focused on the development of recombinant vaccines. A number of different fimbrial types have been used to display immune-relevant sectors of various foreign proteins. Chimeric fimbrial vaccines can be used in the context of purified proteins, however the potential also exists to exploit this technology for the development of live recombinant vaccines. Work has also been performed demonstrating the amenability of fimbriae towards the powerful technology of random peptide display. This review summarises the current state of research in this field.
has issue date	2011-11-01(xsd:dateTime)
bibo:doi	10.1016/s1438-4221(00)80118-6
bibo:pmid	10959723
has license	no-cc
sha1sum (hex)	3e11699a56455350d7118f25e3fff5c81ff6a079
schema:url	https://doi.org/10.1016/s1438-4221%2800%2980118-6
resource representing a document's title	Fimbriae assisted bacterial surface display of heterologous peptides
has PubMed Central identifier	PMC7129006
has PubMed identifier	10959723
schema:publication	Int J Med Microbiol
resource representing a document's body	covid:3e11699a56455350d7118f25e3fff5c81ff6a079#body_text
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