About: Distribution and genetic diversity of adeno-associated viruses in bats from coastal areas of Southeast China

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About: Distribution and genetic diversity of adeno-associated viruses in bats from coastal areas of Southeast China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distribution and genetic diversity of adeno-associated viruses in bats from coastal areas of Southeast China
Creator	Li, Bo Wang, Changjun Wu, Ting Hu, Dan Ai, Lele Ding, Chenxi Lv, Heng Lv, Ruichen Tan, Weilong Wang, Chunhui Wu, Jiahong Yang, Lu Ye, Fuqiang Zhang, Bin Changqiang Zhu,
Source	Medline; PMC
abstract	Bats are associated with several important zoonotic viruses from different families. One example includes adeno-associated viruses (AAVs), that are extensively detected in several animals, especially primates. To understand AAVs distribution and genetic diversity in the coastal areas of Southeast China, a total of 415 intestine samples were mostly collected from two provinces of southeast China, i.e., Zhejiang and Fujian province. Intestine samples from five bat species were collected for AAVs detection. The average prevalence rate for AAV detection among these samples was 18.6% (77 positives out of 415 samples) and ranged from 11.8 to 28.9% between the five bat species. This suggests that AAVs are widely distributed in diverse bat populations in southeast coastal areas of China. Based on the genome sequence of bat adeno-associated virus-CXC1(BtAAV-CXC1) from one AAV-positive sample, the genetic diversity of the detected AAVs were assessed and analyzed. Phylogenetic analysis revealed that BtAAV-CXC1 was comparatively distant to other major AAVs from mammals and non-mammals, with only a 52.9~64.7% nucleotide identity. However, they were phylogenetically closer to Rhinolophus sinicus bat adeno-associated virus (Rs-BtAAV1), with a 74.5% nt similarity. Partial analysis of the rep and cap overlapping open reading frame (ORF) sequences from bat AAV samples revealed 48 partial rep sequences and 23 partial cap sequences from positive samples shared 86.9 to 100% and 72.3 to 98.8% nucleotide identities among themselves, respectively. This suggests that the detected AAVs had a distinctly high genetic diversity. These findings led us to conclude that diverse AAVs may be widely distributed in bat populations from the southeast regions of China.
has issue date	2020-02-28(xsd:dateTime)
bibo:doi	10.1038/s41598-020-60721-z
bibo:pmid	32111911
has license	cc-by
sha1sum (hex)	3e4de1d7982eb2ce67d340a63175adfdab398686
schema:url	https://doi.org/10.1038/s41598-020-60721-z
resource representing a document's title	Distribution and genetic diversity of adeno-associated viruses in bats from coastal areas of Southeast China
has PubMed Central identifier	PMC7048818
has PubMed identifier	32111911
schema:publication	Sci Rep
resource representing a document's body	covid:3e4de1d7982eb2ce67d340a63175adfdab398686#body_text
is schema:about of	named entity 'rep' named entity 'detected' named entity 'AAVs' named entity 'distributed' named entity 'southeast' named entity 'SOUTHEAST' named entity 'COASTAL' named entity 'ADENO-ASSOCIATED VIRUSES' named entity 'DISTANT' named entity 'VIRUSES' named entity 'SIMILARITY' named entity 'NON-' named entity 'POSITIVES' named entity 'CHINA' named entity 'ANALYZED' named entity 'REGIONS' named entity 'DETECTED' named entity 'ASSESSED' named entity 'DISTRIBUTION' named entity 'BAT' named entity 'AREAS' named entity 'SOUTHEAST' named entity 'IDENTITY' named entity 'MAJOR' named entity 'MAY BE' named entity 'PRIMATES' named entity 'CHINA' named entity '100%' named entity 'ANALYSIS' named entity 'BATS' named entity 'AREAS' named entity 'GENETIC DIVERSITY' named entity 'ADENO-ASSOCIATED VIRUSES' named entity 'SPECIES' named entity 'REVEALED' named entity 'REP' named entity 'CAP' named entity 'GENOME SEQUENCE' named entity 'PHYLOGENETIC ANALYSIS' named entity 'POSITIVE' named entity 'FUJIAN PROVINCE' named entity 'BASED' named entity 'MAMMALS' named entity 'DETECTION' named entity 'FAMILIES' named entity 'DIFFERENT' named entity 'ZOONOTIC' named entity 'PARTIAL' named entity 'DISTRIBUTED' named entity 'GENETIC DIVERSITY' named entity 'COLLECTED' named entity 'THESE' named entity 'SAMPLE' named entity 'RHINOLOPHUS SINICUS' named entity 'POPULATIONS' named entity 'ANIMALS' named entity 'SAMPLES' named entity 'FINDINGS' named entity 'UNDERSTAND' named entity 'SHARED' named entity 'HIGH' named entity 'BATS' named entity 'INCLUDES' named entity 'COASTAL' named entity 'LED' named entity 'DISTRIBUTION' named entity 'ADENO-ASSOCIATED VIRUS'

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