About: Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients

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About: Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients
Creator	Kehlen, Astrid Hagemann, Sven Ihling, Christian Sinz, Andrea Arlt, Christian Huẗtelmaier, Stefan Tanzler, Dirk
Source	Medline; PMC
abstract	[Image: see text] Mass spectrometry (MS) can deliver valuable diagnostic data that complement genomic information and allow us to increase our current knowledge of the COVID-19 disease caused by the SARS-CoV-2 virus. We developed a simple, MS-based method to specifically detect SARS-CoV-2 proteins from gargle solution samples of COVID-19 patients. The protocol consists of an acetone precipitation and tryptic digestion of proteins contained within the gargle solution, followed by a targeted MS analysis. Our methodology identifies unique peptides originating from SARS-CoV-2 nucleoprotein. Building on these promising initial results, faster MS protocols can now be developed as routine diagnostic tools for COVID-19 patients. Data are available via ProteomeXchange with identifier PXD019423.
has issue date	2020-06-22(xsd:dateTime)
bibo:doi	10.1021/acs.jproteome.0c00280
bibo:pmid	32568543
has license	no-cc
sha1sum (hex)	3e4e3262093a3cb8aa960caf54b193dee03f6a9f
schema:url	https://doi.org/10.1021/acs.jproteome.0c00280
resource representing a document's title	Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients
has PubMed Central identifier	PMC7315851
has PubMed identifier	32568543
schema:publication	J Proteome Res
resource representing a document's body	covid:3e4e3262093a3cb8aa960caf54b193dee03f6a9f#body_text
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