About: Cell culture propagation of foot-and-mouth disease virus: adaptive amino acid substitutions in structural proteins and their functional implications

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About: Cell culture propagation of foot-and-mouth disease virus: adaptive amino acid substitutions in structural proteins and their functional implications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cell culture propagation of foot-and-mouth disease virus: adaptive amino acid substitutions in structural proteins and their functional implications
Creator	Dill, Veronika Eschbaumer, ·
source	PMC
abstract	Foot-and-mouth disease is endemic in livestock in large parts of Africa and Asia, where it is an important driver of food insecurity and a major obstacle to agricultural development and the international trade in animal products. Virtually all commercially available vaccines are inactivated whole-virus vaccines produced in cell culture, but the adaptation of a field isolate of the virus to growth in culture is laborious and time-consuming. This is of particular concern for the development of vaccines to newly emerging virus lineages, where long lead times from virus isolate to vaccine can delay the implementation of effective control programs. High antigen yields in production cells are also necessary to make vaccines affordable for less developed countries in endemic areas. Therefore, a rational approach to cell culture adaptation that combines prior knowledge of common adaptive mutations and reverse genetics techniques is urgently required. This review provides an overview of amino acid exchanges in the viral capsid proteins in the context of adaptation to cell culture. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11262-019-01714-7) contains supplementary material, which is available to authorized users.
has issue date	2019-11-27(xsd:dateTime)
bibo:doi	10.1007/s11262-019-01714-7
bibo:pmid	31776851
has license	cc-by
sha1sum (hex)	3e6bc3e91e6d1982c44b0382d40a78947e326580
schema:url	https://doi.org/10.1007/s11262-019-01714-7
resource representing a document's title	Cell culture propagation of foot-and-mouth disease virus: adaptive amino acid substitutions in structural proteins and their functional implications
has PubMed Central identifier	PMC6957568
has PubMed identifier	31776851
schema:publication	Virus Genes
resource representing a document's body	covid:3e6bc3e91e6d1982c44b0382d40a78947e326580#body_text
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