About: Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR

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About: Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR
Creator	Ke, Changwen Kang, Min Lu, Jing Yi, Lina Ma, Wenjun Sun, Jiufeng Yuan, Runyu Liu, Zhe Pybus, Oliver Tan, Xiaohua Du Plessis, Louis Lin, Huifang Zeng, Lilian Zhou, Pingping Liang, Chumin Peng, Jinju Xiong, Qianling
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Some COVID-19 cases test positive again for SARS-CoV-2 RNA following negative test results and discharge, raising questions about the meaning of virus detection. Better characterization of re-positive cases is urgently needed. METHODS: Clinical data were obtained through Guangdong's COVID-19 surveillance network. Neutralization antibody titre was determined using microneutralization assays. Potential infectivity of clinical samples was evaluated by cell inoculation. SARS-CoV-2 RNA was detected using three different RT-PCR kits and multiplex PCR with nanopore sequencing. FINDINGS: Among 619 discharged COVID-19 cases, 87 re-tested as SARS-CoV-2 positive in circumstances of social isolation. All re-positive cases had mild or moderate symptoms at initial diagnosis and were younger on average (median, 28). Re-positive cases (n = 59) exhibited similar neutralization antibodies (NAbs) titre distributions to other COVID-19 cases (n = 218) tested here. No infectious strain could be obtained by culture and no full-length viral genomes could be sequenced from re-positive cases. INTERPRETATION: Re-positive SARS-CoV-2 cases do not appear to be caused by active reinfection and were identified in ~14% of discharged cases. A robust NAb response and potential virus genome degradation were detected in almost all re-positive cases, suggesting a substantially lower transmission risk, especially through respiratory routes.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1016/j.ebiom.2020.102960
bibo:pmid	32853988
has license	no-cc
sha1sum (hex)	3e71f58471da312f4d3d2901ec9c02bd6a81d432
schema:url	https://doi.org/10.1016/j.ebiom.2020.102960
resource representing a document's title	Clinical, immunological and virological characterization of COVID-19 patients that test re-positive for SARS-CoV-2 by RT-PCR
has PubMed Central identifier	PMC7444471
has PubMed identifier	32853988
schema:publication	EBioMedicine
resource representing a document's body	covid:3e71f58471da312f4d3d2901ec9c02bd6a81d432#body_text
is schema:about of	named entity 'Clinical' named entity 'caused' named entity 'cases' named entity 'COVID-19' named entity 'discharge' named entity 'cases' named entity 'determined' named entity 'infectivity' named entity 'immunological' named entity 'RISK' named entity 'NEUTRALIZATION' named entity 'CAUSED BY' named entity 'DISTRIBUTIONS' named entity 'IDENTIFIED' named entity 'EVALUATED' named entity 'INFECTIOUS' named entity '27S' named entity 'CLINICAL DATA' named entity 'GENOMES' named entity 'MEANING' named entity 'ROUTES' named entity 'ANTIBODY TITRE' named entity 'MODERATE' named entity 'SURVEILLANCE' named entity 'Guangdong' named entity 'discharged' named entity 'surveillance' named entity 'active' named entity 'COVID-19' named entity 'test' named entity 'Potential' named entity 'nanopore sequencing' named entity 'cases' named entity 'discharged' named entity 'response' named entity 'risk' named entity 'Neutralization' named entity 'diagnosis' named entity 'cases' named entity 'license' named entity 'RT-PCR' named entity 'nanopore sequencing' named entity 'SARS-CoV-2' named entity 'inoculation' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'RT-PCR' named entity 'SARS-CoV-2' named entity 'molecular testing' named entity '28 days' named entity 'genome sequencing' named entity 'COVID' named entity 'Guangdong' named entity 'tested positive' named entity 'primers' named entity 'dry cough' named entity 'COVID-19 infection' named entity 'demographic characteristics' named entity 'nasopharyngeal swabs' named entity 'inflammation' named entity 'RNA' named entity 'multiplex PCR' named entity 'RNA' named entity 'RT-PCR' named entity 'serum'

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